Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COMPLEMENT PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| TNF | degrades | gene | 0.70 |
| TNF | interacts_with | gene | 0.70 |
| MICROGLIA | activates | cell_type | 0.70 |
| MULTIPLE SCLEROSIS | interacts_with | disease | 0.65 |
| NEUROINFLAMMATION | causes | phenotype | 0.65 |
| SYNAPTIC LOSS | causes | phenotype | 0.65 |
| TNF | associated_with | gene | 0.50 |
| TREM2 | associated_with | gene | 0.50 |
| CSF1R | associated_with | gene | 0.50 |
| CX3CR1 | associated_with | gene | 0.50 |
| P2RY12 | associated_with | gene | 0.50 |
| APOE | associated_with | gene | 0.50 |
| CSF | associated_with | phenotype | 0.50 |
| SENESCENCE | associated_with | phenotype | 0.50 |
| ASTROCYTES | associated_with | cell_type | 0.50 |
| ASTROCYTE | associated_with | cell_type | 0.50 |
| CYTOKINES | associated_with | phenotype | 0.50 |
| INFLAMMATION | associated_with | phenotype | 0.50 |
| MICROGLIA | associated_with | cell_type | 0.50 |
| DEMENTIA | associated_with | disease | 0.50 |
| AMYLOID | associated_with | protein | 0.50 |
| APP | associated_with | gene | 0.45 |
| MERTK | associated_with | gene | 0.45 |
| CD68 | associated_with | gene | 0.45 |
| AXL | associated_with | gene | 0.45 |
| NEURODEGENERATION | associated_with | phenotype | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
| GLAUCOMA | associated_with | disease | 0.45 |
| SYNAPTIC LOSS | associated_with | phenotype | 0.45 |
| ALZHEIMER | associated_with | disease | 0.45 |
| DENTATE GYRUS | associated_with | brain_region | 0.45 |
| NEURON | associated_with | cell_type | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CSF1R | inhibits | gene | 0.70 |
| AMYLOID | interacts_with | protein | 0.70 |
| AMYLOID | activates | protein | 0.70 |
| MULTIPLE SCLEROSIS | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||