Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RETINAL DEGENERATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | RETINAL DEGENERATION |
| Key Genes/Proteins | AMYLOID |
| Related Diseases | ALZHEIMER'S DISEASE, OBESITY |
Knowledge base pages for this entity
graph TD
RETINAL_DEGENERATION["RETINAL DEGENERATION"]
RETINAL_DEGENERATION -->|"activates"| Mitochondrial_Function["Mitochondrial Function"]
RETINAL_DEGENERATION -->|"regulates"| Complement["Complement"]
RETINAL_DEGENERATION -->|"regulates"| Epigenetic["Epigenetic"]
RETINAL_DEGENERATION -->|"activates"| Phagocytosis["Phagocytosis"]
RETINAL_DEGENERATION -->|"activates"| Oxidative_Stress["Oxidative Stress"]
RETINAL_DEGENERATION -->|"activates"| Lipid_Metabolism["Lipid Metabolism"]
RETINAL_DEGENERATION -->|"activates"| Cholesterol["Cholesterol"]
RETINAL_DEGENERATION -->|"causes"| Amyloid["Amyloid"]
__amyloid["beta-amyloid"] -->|"causes"| RETINAL_DEGENERATION
MYO7A["MYO7A"] -->|"activates"| RETINAL_DEGENERATION
UBIQUITIN["UBIQUITIN"] -->|"activates"| RETINAL_DEGENERATION
NRL["NRL"] -->|"activates"| RETINAL_DEGENERATION
GENES["GENES"] -->|"activates"| RETINAL_DEGENERATION
COMPLEMENT["COMPLEMENT"] -->|"regulates"| RETINAL_DEGENERATION
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| RETINAL_DEGENERATION
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| RETINAL_DEGENERATION| Target | Relation | Type | Str |
|---|---|---|---|
| Astrocyte Reactivity | activates | pathway | 0.55 |
| Mitochondrial Function | activates | pathway | 0.55 |
| Complement | regulates | pathway | 0.55 |
| Epigenetic | regulates | pathway | 0.55 |
| Phagocytosis | activates | pathway | 0.55 |
| Oxidative Stress | activates | pathway | 0.55 |
| Lipid Metabolism | activates | pathway | 0.55 |
| Cholesterol | activates | pathway | 0.55 |
| Amyloid | causes | pathway | 0.55 |
| Alpha-Synuclein | activates | pathway | 0.55 |
| Microglia Activation | activates | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | causes | disease | 0.35 |
| AMYLOID | causes | protein | 0.35 |
| RETINA | causes | brain_region | 0.35 |
| OBESITY | causes | disease | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||