concept

SYNAPTIC LOSS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC LOSS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections

0Hypotheses

5Analyses

19Outgoing

35Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SYNAPTIC LOSS
Key Genes/Proteins	AMYLOID
Related Diseases	COGNITIVE DECLINE, NEUROINFLAMMATION, OXIDATIVE STRESS, COMPLEMENT ACTIVATION, ALZHEIMER'S DISEASE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SYNAPTIC_LOSS["SYNAPTIC LOSS"]
    SYNAPTIC_LOSS -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    SYNAPTIC_LOSS -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    SYNAPTIC_LOSS -.biomarker for.-> Depression["Depression"]
    C1q_C3_CR3_signaling_pathway["C1q/C3-CR3 signaling pathway"] -->|"causes"| SYNAPTIC_LOSS
    Abnormal_Microglial_Phagocytos["Abnormal Microglial Phagocytosis"] -->|"causes"| SYNAPTIC_LOSS
    TREM2["TREM2"] -.protects against.-> SYNAPTIC_LOSS
    MICROGLIA["MICROGLIA"] -->|"mediates"| SYNAPTIC_LOSS
    Impaired_Mitophagy["Impaired Mitophagy"] -->|"causes"| SYNAPTIC_LOSS
    Microglial_Phagocytosis["Microglial Phagocytosis"] -->|"causes"| SYNAPTIC_LOSS
    Microglia["Microglia"] -->|"causes"| SYNAPTIC_LOSS
    COMPLEMENT_ACTIVATION["COMPLEMENT ACTIVATION"] -->|"contributes to"| SYNAPTIC_LOSS

Outgoing (25)

Target	Relation	Type	Str
HIPPOCAMPUS	regulates	brain_region	0.70
HIPPOCAMPUS	activates	brain_region	0.70
COGNITIVE DECLINE	treats	phenotype	0.70
NEURODEGENERATION	interacts_with	phenotype	0.65
NEURODEGENERATION	biomarker_for	disease	0.60
CORTEX	associated_with	brain_region	0.50
MELATONIN	associated_with	drug	0.50
DASATINIB	associated_with	drug	0.50
QUERCETIN	associated_with	drug	0.50
CA1	associated_with	brain_region	0.50
AXONAL TRANSPORT	associated_with	phenotype	0.50
CA3	associated_with	brain_region	0.50
MMSE	associated_with	biomarker	0.50
DENTATE GYRUS	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
HYPOTHALAMUS	associated_with	brain_region	0.45
THALAMUS	associated_with	brain_region	0.45
AMYGDALA	associated_with	brain_region	0.45
WNT SIGNALING	associated_with	pathway	0.45

Incoming (58)

Source	Relation	Type	Str
MICROGLIA	mediates	entity	0.90
COMPLEMENT ACTIVATION	contributes_to	entity	0.85
CORTEX	causes	brain_region	0.70
CORTEX	regulates	brain_region	0.70
NEUROINFLAMMATION	causes	phenotype	0.70
OXIDATIVE STRESS	activates	phenotype	0.70
OXIDATIVE STRESS	regulates	phenotype	0.70
COMPLEMENT ACTIVATION	causes	phenotype	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
AMYLOID	activates	protein	0.70
NEURONS	treats	cell_type	0.70
AGING	activates	phenotype	0.70
AMYLOID	causes	protein	0.65
TREM2	regulates	gene	0.65
TREM2	causes	gene	0.65
AMYLOID	interacts_with	protein	0.65
NEUROINFLAMMATION	treats	phenotype	0.65
MICROGLIA	regulates	cell_type	0.65
COMPLEMENT PATHWAY	causes	pathway	0.65
ER STRESS	protects_against	phenotype	0.65
HIPPOCAMPUS	causes	brain_region	0.65
TAU	phosphorylates	protein	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
MICROGLIA	activates	cell_type	0.65
MICROGLIA	inhibits	cell_type	0.65
PSEN1	causes	gene	0.65
NEURON	causes	cell_type	0.65
TAU	activates	protein	0.65
AMYLOID	implicated_in	protein	0.55
ENTORHINAL CORTEX	associated_with	brain_region	0.50
COMPLEMENT CASCADE	associated_with	pathway	0.50
COMPLEMENT PATHWAY	associated_with	pathway	0.45
AMYLOID	associated_with	protein	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

Is C1q elevation in AD pathogenic or compensatory for amyloid clearance?

neurodegeneration | 2026-04-12 | 0 hypotheses

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

neurodegeneration | 2026-04-08 | 0 hypotheses

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

synaptic biology | 2026-04-07 | 0 hypotheses

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-06 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SYNAPTIC LOSS

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

Parthanatos in Neurodegeneration

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

Neuroresilience Mechanisms and Evidence

NPM1 Gene

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Multiple System Atrophy

Alzheimer's Disease

Frontotemporal Dementia (FTD)

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

GSK-3β in Neurodegeneration

Pathway Diagram

Outgoing (25)

Incoming (58)

Targeting Hypotheses (0)

Mentioning Analyses (5)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Is C1q elevation in AD pathogenic or compensatory for amyloid clearance?

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Related Papers (0)