Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DSP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DSP |
| Key Genes/Proteins | DES, IBA1, BAG3, GFAP |
| Related Diseases | Ischemia, Stroke, Aging, Fibrosis, Alzheimer |
| Related Pathways | Neuroinflammatory, Apoptosis, Autophagy |
Knowledge base pages for this entity
graph TD
DSP["DSP"]
DSP -->|"causes"| Ischemia["Ischemia"]
DSP -->|"activates"| Aging["Aging"]
DSP -->|"activates"| Fibrosis["Fibrosis"]
DSP -->|"activates"| Alzheimer["Alzheimer"]
DSP -->|"activates"| Als["Als"]
DSP -->|"activates"| Cerebral_Amyloid_Angiopathy["Cerebral Amyloid Angiopathy"]
DSP -->|"causes"| IBA1["IBA1"]
DES["DES"] -->|"co_expressed_with"| DSP
GFAP["GFAP"] -->|"regulates"| DSP
AUTOPHAGY["AUTOPHAGY"] -->|"causes"| DSP
CTSD["CTSD"] -->|"causes"| DSP
AND["AND"] -->|"regulates"| DSP
MAP2["MAP2"] -->|"causes"| DSP
APOPTOSIS["APOPTOSIS"] -->|"causes"| DSP| Target | Relation | Type | Str |
|---|---|---|---|
| Ischemia | causes | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cerebral Amyloid Angiopathy | activates | disease | 0.65 |
| IBA1 | causes | gene | 0.60 |
| BAG3 | causes | gene | 0.60 |
| Neuroinflammatory | associated_with | pathway | 0.60 |
| Apoptosis | causes | pathway | 0.60 |
| Autophagy | causes | pathway | 0.60 |
| GFAP | regulates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| IBA1 | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Microglia | activates | cell_type | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| RNA | activates | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| TREM2 | activates | gene | 0.60 |
| Immune Response | activates | pathway | 0.60 |
| Blood-Brain Barrier | activates | pathway | 0.60 |
| Macrophage | activates | cell_type | 0.60 |
| Aβ | activates | protein | 0.60 |
| BAG3 | activates | gene | 0.60 |
| MAP2 | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| stroke | associated_with | disease | 0.60 |
| neuroinflammation | associated_with | disease | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Microglia | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DES | co_expressed_with | gene | 0.80 |
| GFAP | regulates | gene | 0.60 |
| AUTOPHAGY | causes | gene | 0.60 |
| CTSD | causes | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| MAP2 | causes | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| APOPTOSIS | causes | gene | 0.60 |
| MAP2 | activates | gene | 0.60 |
| BAG3 | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALS | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||