Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DUSP10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DUSP10 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, therapeutic target. Associated with Als, Alzheimer, Ms. Connected to 20 entities in the SciDEX knowledge graph.
| Gene Symbol | DUSP10 |
| Protein Type | Phosphatase |
| Function | is a member of the dual-specificity phosphatase family that specifically dephosphorylates and inactivates both JNK (c-Jun N-terminal Kinase) and p38 MAPK pathways. |
| Amino Acids | 482 aa |
| Pathways | MAPK, MAPK pathway |
| Ensembl ID | ENSG00000143507 |
| GeneCards | DUSP10 |
| Human Protein Atlas | DUSP10 |
| N-terminal Non-catalytic Domain | Contains binding sites for MAPK substrates and regulators |
| Phosphatase Catalytic Domain | Contains the HCX5R active site motif essential for phosphatase activity |
| Nuclear Export Signal (NES) | Allows shuttling between nucleus and cytoplasm |
| Associated Diseases | Als, Alzheimer, Ms |
| Interactions | TAU, NEUROTOXICITY, ALZHEIMER'S DISEASE, P38, MIRNAS, APOPTOSIS |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DUSP10["<b>DUSP10</b>"]
Alzheimer{"Alzheimer"}
DUSP10 -->|"associated with"| Alzheimer
Als{"Als"}
DUSP10 -->|"associated with"| Als
Ms{"Ms"}
DUSP10 -->|"associated with"| Ms
MAP1S["MAP1S"]
DUSP10 -->|"associated with"| MAP1S
PSP["PSP"]
DUSP10 -->|"associated with"| PSP
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
DUSP10 -->|"associated with"| ALZHEIMER_S_DISEASE
ASTROCYTES["ASTROCYTES"]
DUSP10 -->|"associated with"| ASTROCYTES
SP1["SP1"]
DUSP10 -->|"associated with"| SP1
APOE["APOE"]
DUSP10 -->|"associated with"| APOE
TAU["TAU"]
DUSP10 -->|"associated with"| TAU
KIF13A["KIF13A"]
DUSP10 -->|"associated with"| KIF13A
TRIM24["TRIM24"]
DUSP10 -->|"associated with"| TRIM24
style DUSP10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| MAP1S | associated_with | gene | 0.60 |
| PSP | associated_with | gene | 0.60 |
| SP1 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| KIF13A | associated_with | gene | 0.60 |
| TRIM24 | associated_with | gene | 0.60 |
| STX6 | associated_with | gene | 0.60 |
| MAPT | associated_with | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| EIF2AK3 | regulates | gene | 0.60 |
| MAPT | regulates | gene | 0.60 |
| PSP | regulates | gene | 0.60 |
| STX6 | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| NEUROTOXICITY | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Tau Phosphorylation | activates | pathway | 0.60 |
| Mapk | activates | pathway | 0.60 |
| MOBP | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||