concept

ENDOCYTOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOCYTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

687Connections

0Hypotheses

0Analyses

1Outgoing

49Incoming

Summary

ENDOCYTOSIS is a concept in neurodegeneration research. Key relationships include: activates, co discussed, degrades. Connected to 18 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ENDOCYTOSIS
Key Genes/Proteins	TFEB, MTORC1, APOE, C1Q, GPR37, TREM2

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ENDOCYTOSIS["ENDOCYTOSIS"]
    ENDOCYTOSIS -->|"activates"| MTORC1["MTORC1"]
    ENDOCYTOSIS -->|"interacts"| Complement["Complement"]
    ENDOCYTOSIS -->|"interacts"| Exocytosis["Exocytosis"]
    ENDOCYTOSIS -->|"interacts"| Angiogenesis["Angiogenesis"]
    ENDOCYTOSIS -->|"interacts"| Apoptosis["Apoptosis"]
    ENDOCYTOSIS -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    ENDOCYTOSIS -->|"interacts"| Autophagy["Autophagy"]
    TFEB["TFEB"] -->|"activates"| ENDOCYTOSIS
    PIEZO1["PIEZO1"] -->|"activates"| ENDOCYTOSIS
    TARDBP["TARDBP"] -->|"expressed in"| ENDOCYTOSIS
    NTN1["NTN1"] -->|"expressed in"| ENDOCYTOSIS
    SNRNP70["SNRNP70"] -->|"expressed in"| ENDOCYTOSIS
    JUN["JUN"] -->|"expressed in"| ENDOCYTOSIS
    NTN3["NTN3"] -->|"expressed in"| ENDOCYTOSIS

Outgoing (71)

Target	Relation	Type	Str
MTORC1	activates	protein	0.64

Incoming (616)

Source	Relation	Type	Str
TFEB	activates	protein	0.72
APOE	neuroprotective	gene	0.55
APOE	involved_in	gene	0.55
C1Q	involved_in	gene	0.55
C1Q	activates	gene	0.55
C1Q	inhibits	gene	0.55
GPR37	regulates	gene	0.55
GPR37	involved_in	gene	0.55
GPR37	activates	gene	0.55
TREM2	has_variant	gene	0.55
BMAL1	activates	gene	0.55
PIEZO1	modifies	gene	0.55
LDLR	regulates	gene	0.55
FOXO1	activates	gene	0.55
GLP1R	activates	gene	0.55
PLIN2	activates	gene	0.55
SIRT3	activates	gene	0.55
SREBF2	activates	gene	0.55
STING1	activates	gene	0.55
STX17	activates	gene	0.55
ULK1	activates	gene	0.55
TET2	activates	gene	0.55
FOXP3	involved_in	gene	0.55
FOXP3	expression	gene	0.55
ABCA1	involved_in	gene	0.55
LRP1	inhibits	gene	0.55
TREM2	involved_in	gene	0.55
TREM2	inhibits	gene	0.55
TREM2	neurotoxic	gene	0.55
VCP	involved_in	gene	0.55
TLR4	inhibits	gene	0.55
TREM2	activates	gene	0.55
C1Q	expression	gene	0.55
FLOT1	involved_in	gene	0.55
LRP1	activates	gene	0.55
MLCK	inhibits	gene	0.55
P2RX7	expression	gene	0.55
NLRP3	activates	gene	0.55
TREM2	expression	gene	0.55
CX3CR1	involved_in	gene	0.55
BMAL1	expression	gene	0.55
CLOCK	expression	gene	0.55
TREM2	regulates	gene	0.55
MAPT	inhibits	gene	0.55
CAV1	modifies	gene	0.55
TLR4	activates	gene	0.55
TLR4	involved_in	gene	0.55
HDAC3	neurotoxic	gene	0.55
IL1B	expression	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ENDOCYTOSIS

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Alpha-Synuclein Pathology

GRIA3 Gene

Alzheimer's Disease

Astrocyte Reactivity Mechanism

Mitochondrial Dysfunction in Parkinson's Disease

CLCN10 — Chloride Voltage-Gated Channel 10

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Tau Spreading Mechanism

APOC4 — Apolipoprotein C-IV

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

gabaergic-dysfunction

TREM2 Microglial Signaling Pathway in Neurodegeneration

dendritic-spines

Synaptic Vesicle Trafficking in Parkinson's Disease

psp-tauopathy

Niemann-Pick Disease Type C (NPC)