protein

C-FOS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C-FOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

261Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

C-FOS is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Als, Alzheimer. Connected to 129 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	C-FOS
Primary Expression	Prefrontal Cortex, Cortex, Thalamus, Hypothalamus, Spinal Cord
Molecular Weight	62 kDa
Amino Acids	380 aa
Pathways	MAPK pathway
GeneCards	C-FOS
Human Protein Atlas	C-FOS
Associated Diseases	Als
Interactions	IL-6, C-JUN, JUN, OXIDATIVE STRESS, CAT, JUND
KG Connections	255 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    C_FOS["C-FOS"]
    C_FOS -->|"upregulates"| EPHA5["EPHA5"]
    C_FOS -->|"regulates"| neural_plasticity["neural plasticity"]
    C_FOS -->|"contributes to"| Anxiety["Anxiety"]
    C_FOS -->|"contributes to"| Ms["Ms"]
    C_FOS -->|"activates"| Als["Als"]
    C_FOS -->|"activates"| Leukemia["Leukemia"]
    C_FOS -->|"activates"| Tumor["Tumor"]
    psilocybin["psilocybin"] -->|"activates"| C_FOS
    ketamine["ketamine"] -->|"activates"| C_FOS
    FOS["FOS"] -->|"activates"| C_FOS
    EPO["EPO"] -->|"activates"| C_FOS
    JUNB["JUNB"] -->|"activates"| C_FOS
    MYC["MYC"] -->|"activates"| C_FOS
    CYTOKINES["CYTOKINES"] -->|"expressed in"| C_FOS
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| C_FOS
    TNF["TNF"] -->|"activates"| C_FOS

Outgoing (166)

Target	Relation	Type	Str
Als	activates	disease	0.75
Als	expressed_in	disease	0.75
Inflammation	activates	disease	0.75
JUN	activates	gene	0.70
TNF-Α	activates	gene	0.70
Anxiety	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Als	associated_with	disease	0.65
Leukemia	activates	disease	0.65
Tumor	activates	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Migraine	activates	disease	0.65
Ischemia	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Depression	activates	disease	0.65
Retinopathy	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	activates	disease	0.65
ALS	regulates	disease	0.65
Epilepsy	activates	disease	0.65
Depression	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Fibrosis	inhibits	disease	0.65
Autophagy	associated_with	pathway	0.60
IL-6	activates	gene	0.60
C-JUN	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
CAT	activates	gene	0.60
JUND	activates	gene	0.60
C-JUN	expressed_in	gene	0.60
PKC	regulates	gene	0.60
JUN	expressed_in	gene	0.60
PKC	activates	gene	0.60
MAF	regulates	gene	0.60
NRF2	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
SIRT1	activates	gene	0.60
BMAL1	activates	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
Circadian Rhythm	activates	pathway	0.60
STAT3	inhibits	gene	0.60
TNF	activates	gene	0.60

Incoming (95)

Source	Relation	Type	Str
FOS	activates	gene	0.70
FOS	expressed_in	gene	0.70
TNF	activates	gene	0.70
FOS	regulates	gene	0.70
CYTOKINES	activates	gene	0.70
FOS	associated_with	gene	0.60
EPO	activates	gene	0.60
JUNB	activates	gene	0.60
MYC	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
NRF1	activates	gene	0.60
FOS	inhibits	gene	0.60
SRC	inhibits	gene	0.60
GFAP	activates	gene	0.60
ASTROCYTES	regulates	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
TLR4	activates	gene	0.60
GAPDH	activates	gene	0.60
VHL	activates	gene	0.60
MBD1	activates	gene	0.60
CREB	activates	gene	0.60
C-JUN	activates	gene	0.60
ERK	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
STAT3	activates	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
BDNF	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
FOS	implicated_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
NOTCH1	activates	gene	0.60
PARKINSON	activates	gene	0.60
IL-6	activates	gene	0.60
HES5	activates	gene	0.60
C-JUN	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
SIRT1	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
BMAL1	activates	gene	0.60
SIRT1	activates	gene	0.60
GENES	activates	gene	0.60
CAT	activates	gene	0.60
NRF2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

C-FOS

Understanding Entity Pages

Summary

Wiki Pages (20)

NTF4 Protein

Neurotrophin Signaling Pathways in Neurodegeneration

CREB Signaling in Neurodegeneration

IGF-1 Signaling Pathway in Neurodegeneration

NF-kB Signaling Pathway in Neurodegeneration

RASGRP1 Gene

Amyloid Precursor Protein (APP)

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

Histone Modification Pathways in Neurodegeneration

CORT108297 Phase 2 (NCT04601038) - Stress Attenuation in AD

MAPK/ERK Signaling Pathway in Neurodegeneration

Oxytocin Receptor Neurons

erk-mapk-signaling-neurodegeneration

Fear Conditioning

ERK1 Protein

ERK2 Protein

cxcr4

Integrated Stress Response in Alzheimer's Disease