Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EWSR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
EWSR1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, associated with. Associated with Als, Cancer, Ms. Connected to 23 entities in the SciDEX knowledge graph.
| Gene Symbol | EWSR1 |
| Full Name | Ewing Sarcoma Breakpoint Region 1 |
| Chromosome | 22q12.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 68.5 kDa |
| Amino Acids | 655 aa |
| Exons | 17 |
| Pathways | oxidative stress response |
| UniProt ID | Q01844 |
| NCBI Gene ID | 2130 |
| Ensembl ID | ENSG00000182944 |
| OMIM | 133450 |
| GeneCards | EWSR1 |
| Human Protein Atlas | EWSR1 |
| Associated Diseases | ALS |
| Interactions | Rb, FUS, CANCER, P53, AND, RNA |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
EWSR1["<b>EWSR1</b>"]
Ms{"Ms"}
EWSR1 -->|"expressed in"| Ms
Cancer{"Cancer"}
EWSR1 -->|"expressed in"| Cancer
EWSR1 -->|"therapeutic target"| Cancer
DDIT3["DDIT3"]
EWSR1 -->|"associated with"| DDIT3
YBX1["YBX1"]
EWSR1 -->|"therapeutic target"| YBX1
NATURAL_COMPOUNDS["NATURAL COMPOUNDS"]
EWSR1 -->|"therapeutic target"| NATURAL_COMPOUNDS
MECP2["MECP2"]
EWSR1 -->|"therapeutic target"| MECP2
CANCER["CANCER"]
EWSR1 -->|"therapeutic target"| CANCER
HSPA1A["HSPA1A"]
EWSR1 -->|"therapeutic target"| HSPA1A
APOPTOSIS["APOPTOSIS"]
EWSR1 -->|"therapeutic target"| APOPTOSIS
SYNCRIP["SYNCRIP"]
EWSR1 -->|"therapeutic target"| SYNCRIP
G3BP1["G3BP1"]
EWSR1 -->|"therapeutic target"| G3BP1
TAF15["TAF15"]
TAF15 -->|"associated with"| EWSR1
FUS["FUS"]
FUS -->|"associated with"| EWSR1
FLAVONOIDS["FLAVONOIDS"]
FLAVONOIDS -->|"therapeutic target"| EWSR1
IGF2BP1["IGF2BP1"]
IGF2BP1 -->|"therapeutic target"| EWSR1
style EWSR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Circfrmd4A | promotes | compound | 0.90 |
| circFRMD4A | associated_with | compound | 0.88 |
| Ms | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| DDIT3 | associated_with | gene | 0.60 |
| YBX1 | therapeutic_target | gene | 0.60 |
| MECP2 | therapeutic_target | gene | 0.60 |
| HSPA1A | therapeutic_target | gene | 0.60 |
| SYNCRIP | therapeutic_target | gene | 0.60 |
| G3BP1 | therapeutic_target | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| NATURAL COMPOUNDS | therapeutic_target | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| CANCER | activates | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| FRMD4A | activates | gene | 0.60 |
| PKM2 | activates | gene | 0.60 |
| P53 | encodes | gene | 0.60 |
| FRMD4A | encodes | gene | 0.60 |
| RNA | encodes | gene | 0.60 |
| Raf | activates | protein | 0.60 |
| FUS | interacts_with | gene | 0.55 |
| RNA | binds_to | gene | 0.55 |
| RNA | interacts_with | gene | 0.55 |
| oxidative stress response | participates_in | pathway | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||