Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NATURAL COMPOUNDS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NATURAL COMPOUNDS is a concept in neurodegeneration research. Key relationships include: therapeutic target, activates, regulates. Associated with ALS, Aging, Als. Connected to 252 entities in the SciDEX knowledge graph.
| Name | NATURAL COMPOUNDS |
| Key Genes/Proteins | APOPTOSIS, INFLAMMATION, CANCER, OXIDATIVE STRESS, AKT, AUTOPHAGY |
| Related Diseases | Inflammation, Cancer, Als, Tumor |
| Related Pathways | Apoptosis, Oxidative Stress, Autophagy |
Knowledge base pages for this entity
graph TD
NATURAL_COMPOUNDS["NATURAL COMPOUNDS"]
NATURAL_COMPOUNDS -->|"activates"| AMPK["AMPK"]
NATURAL_COMPOUNDS -->|"target for"| Ms["Ms"]
NATURAL_COMPOUNDS -->|"target for"| Inflammation["Inflammation"]
NATURAL_COMPOUNDS -->|"target for"| Autoimmune["Autoimmune"]
NATURAL_COMPOUNDS -->|"activates"| Als["Als"]
NATURAL_COMPOUNDS -->|"target for"| Cancer["Cancer"]
NATURAL_COMPOUNDS -->|"activates"| Tumor["Tumor"]
NATURAL_COMPOUNDS -->|"target for"| Neurodegeneration["Neurodegeneration"]
NATURAL_COMPOUNDS -->|"target for"| Neuroinflammation["Neuroinflammation"]
ERK["ERK"] -->|"target for"| NATURAL_COMPOUNDS
JAK["JAK"] -->|"target for"| NATURAL_COMPOUNDS
PI3K["PI3K"] -->|"target for"| NATURAL_COMPOUNDS
AKT["AKT"] -->|"target for"| NATURAL_COMPOUNDS
INFLAMMATION["INFLAMMATION"] -->|"target for"| NATURAL_COMPOUNDS
NF__B["NF-KappaB"] -->|"target for"| NATURAL_COMPOUNDS
SHH["SHH"] -->|"target for"| NATURAL_COMPOUNDS
CDK1["CDK1"] -->|"activates"| NATURAL_COMPOUNDS
MICROGLIA["MICROGLIA"] -->|"target for"| NATURAL_COMPOUNDS
FLAVONOIDS["FLAVONOIDS"] -->|"target for"| NATURAL_COMPOUNDS| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | therapeutic_target | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Tumor | therapeutic_target | disease | 0.95 |
| AKT | therapeutic_target | gene | 0.90 |
| AUTOPHAGY | therapeutic_target | gene | 0.90 |
| Autophagy | therapeutic_target | pathway | 0.90 |
| Als | inhibits | disease | 0.85 |
| PI3K | therapeutic_target | gene | 0.80 |
| Pi3K/Akt | therapeutic_target | pathway | 0.80 |
| Blood-Brain Barrier | therapeutic_target | pathway | 0.80 |
| Tumor | activates | disease | 0.75 |
| Neurodegeneration | therapeutic_target | disease | 0.75 |
| Ischemia | therapeutic_target | disease | 0.75 |
| Cancer | activates | disease | 0.75 |
| Leukemia | therapeutic_target | disease | 0.75 |
| Tumor | inhibits | disease | 0.75 |
| Cancer | regulates | disease | 0.75 |
| Stroke | therapeutic_target | disease | 0.75 |
| AMPK | activates | gene | 0.70 |
| NRF2 | regulates | gene | 0.70 |
| CANCER | activates | gene | 0.70 |
| Apoptosis | activates | pathway | 0.70 |
| Mitochondrial Function | therapeutic_target | pathway | 0.70 |
| GPX4 | regulates | gene | 0.70 |
| FERROPTOSIS | regulates | gene | 0.70 |
| Ferroptosis | regulates | pathway | 0.70 |
| GENES | activates | gene | 0.70 |
| OVERVIEW | inhibits | gene | 0.70 |
| GENES | therapeutic_target | gene | 0.70 |
| MTOR | therapeutic_target | gene | 0.70 |
| Mtor | therapeutic_target | pathway | 0.70 |
| CANCER | regulates | gene | 0.70 |
| NF-ΚB | inhibits | gene | 0.70 |
| OVERVIEW | therapeutic_target | gene | 0.70 |
| Nf-Κb | inhibits | pathway | 0.70 |
| STROKE | therapeutic_target | gene | 0.70 |
| Neurogenesis | therapeutic_target | pathway | 0.70 |
| Ms | therapeutic_target | disease | 0.65 |
| Autoimmune | therapeutic_target | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Autoimmune | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC7A11 | regulates | gene | 0.70 |
| MIRNAS | activates | gene | 0.70 |
| ERK | therapeutic_target | gene | 0.60 |
| JAK | therapeutic_target | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
| NF-ΚB | therapeutic_target | gene | 0.60 |
| SHH | therapeutic_target | gene | 0.60 |
| CDK1 | activates | gene | 0.60 |
| MICROGLIA | therapeutic_target | gene | 0.60 |
| FLAVONOIDS | therapeutic_target | gene | 0.60 |
| NEURODEGENERATION | therapeutic_target | gene | 0.60 |
| TLR | therapeutic_target | gene | 0.60 |
| TLR4 | therapeutic_target | gene | 0.60 |
| MYD88 | therapeutic_target | gene | 0.60 |
| CYTOKINES | therapeutic_target | gene | 0.60 |
| ASTROCYTES | therapeutic_target | gene | 0.60 |
| FLAVONOIDS | activates | gene | 0.60 |
| IGF2BP1 | therapeutic_target | gene | 0.60 |
| EWSR1 | therapeutic_target | gene | 0.60 |
| YBX1 | therapeutic_target | gene | 0.60 |
| EXOSOMES | associated_with | gene | 0.60 |
| CD44 | activates | gene | 0.60 |
| FERROPTOSIS | inhibits | gene | 0.60 |
| TFR1 | activates | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 0.60 |
| HO-1 | regulates | gene | 0.60 |
| NRF2 | regulates | gene | 0.60 |
| MIRNAS | therapeutic_target | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| MAPK | therapeutic_target | gene | 0.60 |
| NEUROINFLAMMATION | therapeutic_target | gene | 0.60 |
| STROKE | therapeutic_target | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| TNFR1 | inhibits | gene | 0.60 |
| NF-ΚB | inhibits | gene | 0.60 |
| TNFR2 | inhibits | gene | 0.60 |
| TNF-Α | inhibits | gene | 0.60 |
| OVERVIEW | therapeutic_target | gene | 0.60 |
| WNT | therapeutic_target | gene | 0.60 |
| INSULIN RESISTANCE | therapeutic_target | gene | 0.60 |
| YAP | therapeutic_target | gene | 0.60 |
| MAPK | protects_against | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||