Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MBD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | MBD2 |
| Full Name | Methyl-CpG Binding Domain Protein 2 |
| Aliases | Page for MBD2 Gene, Page for MBD2 Protein |
| Chromosome | 18q21.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the brain with particularly high levels in: |
| Molecular Weight | 46 kDa |
| Amino Acids | 80 aa |
| UniProt ID | Q9UBT4 |
| NCBI Gene ID | 8932 |
| Ensembl ID | ENSG00000134046 |
| OMIM | 605078 |
| GeneCards | MBD2 |
| Human Protein Atlas | MBD2 |
| Associated Diseases | Ms |
| Interactions | ABCB1, KMT2A |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MBD2["<b>MBD2</b>"]
Carcinoma{"Carcinoma"}
MBD2 -->|"regulates"| Carcinoma
Ms{"Ms"}
MBD2 -->|"associated with"| Ms
Tumor{"Tumor"}
MBD2 -->|"activates"| Tumor
ABCB1["ABCB1"]
MBD2 -->|"activates"| ABCB1
KMT2A["KMT2A"]
MBD2 -->|"activates"| KMT2A
neurodegeneration["neurodegeneration"]
MBD2 -->|"implicated in"| neurodegeneration
style MBD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Carcinoma | regulates | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| ABCB1 | activates | gene | 0.60 |
| KMT2A | activates | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| MAPK14 | expressed_in | gene | 0.60 |
| ERK1/2 | expressed_in | gene | 0.60 |
| MAPK | expressed_in | gene | 0.60 |
| Dna Methylation | expressed_in | pathway | 0.60 |
| Epigenetic | expressed_in | pathway | 0.60 |
| Erk | expressed_in | protein | 0.60 |
| Ras | expressed_in | protein | 0.60 |
| Pi3K | expressed_in | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||