concept

NF-κB SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-κB SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

1Hypotheses

8Analyses

15Outgoing

34Incoming

0Experiments

15Debates

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💡 Concept Info

Name	NF-κB SIGNALING

Pathway Diagram

graph TD
    NF__B_SIGNALING["NF-kappaB SIGNALING"]
    NF__B_SIGNALING -->|"activates"| Inflammatory_Cytokine_Producti["Inflammatory Cytokine Production"]
    NF__B_SIGNALING -->|"activates"| Inflammation["Inflammation"]
    NF__B_SIGNALING -->|"promotes"| platelet_activation["platelet activation"]
    NF__B_SIGNALING -->|"promotes"| microvascular_thrombosis["microvascular thrombosis"]
    NF__B_SIGNALING -->|"interacts"| PI3K_AKT["PI3K/AKT"]
    NF__B_SIGNALING -->|"interacts"| AKT["AKT"]
    NF__B_SIGNALING -->|"mediates"| Macrophage_activation["Macrophage activation"]
    NF__B_SIGNALING -->|"activates"| inflammatory_cytokines["inflammatory cytokines"]
    NLRP6["NLRP6"] -->|"regulates"| NF__B_SIGNALING
    TAB1["TAB1"] -->|"upstream_of"| NF__B_SIGNALING
    Mitochondrial_Stress["Mitochondrial Stress"] -->|"activates"| NF__B_SIGNALING
    TRAF6["TRAF6"] -->|"upstream_of"| NF__B_SIGNALING
    ZBP1["ZBP1"] -->|"activates"| NF__B_SIGNALING
    CLU["CLU"] -->|"inhibits"| NF__B_SIGNALING
    PIMREG["PIMREG"] -->|"activates"| NF__B_SIGNALING
    COPA_mutations["COPA mutations"] -->|"activates"| NF__B_SIGNALING

Outgoing (15)

Target	Relation	Type	Str
Inflammatory Cytokine Production	activates	process	0.95
platelet activation	promotes	process	0.90
microvascular thrombosis	promotes	process	0.90
Inflammation	activates	process	0.90
Cisplatin Resistance	associated_with	phenotype	0.90
IL1B	upregulates	gene	0.88
IL6	upregulates	gene	0.88
TNF	upregulates	gene	0.88
Allergic Airway Inflammation	mediates	disease	0.88
PI3K/AKT	interacts_with	pathway	0.85
AKT	interacts_with	protein	0.82
Macrophage activation	mediates	cell_type	0.80
neuroinflammation	causes	phenotype	0.70
inflammatory loop	causes	phenotype	0.70
inflammatory cytokines	activates	protein	0.70

Incoming (34)

Source	Relation	Type	Str
NLRP6	regulates	protein	0.95
TAB1	upstream_of	protein	0.92
Lapiferin	inhibits	compound	0.92
37069623	promotes	paper	0.90
miR-155	activates	gene	0.90
TLR4	activates	protein	0.90
Mitochondrial Stress	activates	process	0.90
Manganese	activates	compound	0.90
TNF-α	activates	protein	0.90
TRAF6	upstream_of	protein	0.90
ZBP1	activates	protein	0.90
H1N1 Virus	activates	process	0.85
COPA mutations	activates	mechanism	0.85
Mitophagy	associated_with	process	0.85
CLU	inhibits	protein	0.85
PIMREG	activates	protein	0.85
COPA Mutations	activates	mechanism	0.85
PLCB3	associated_with	gene	0.80
Small Extracellular Vesicles	inhibits	biomarker	0.80
LRP1	activates	gene	0.80
DRD2	inhibits	gene	0.70
NEMO	activates	protein	0.70
SIRT6	inhibits	gene	0.70
TGR5 inactivation	associated_with	phenotype	0.70
TLR4	activates	gene	0.70
TNF-α	activates	cytokine	0.70
mitophagy	associated_with	process	0.70
TREM2	modulates	protein	0.70
Trem2	inhibits	protein	0.70
GPR43 activation	suppresses	pathway	0.70
TNF	upstream_of	gene	0.60
39817909	dampen	paper	0.60
HCRTR1	involved_in	gene	0.60
Alectinib	inhibits	drug	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target	0.619	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M

Mentioning Analyses (8)

Scientific analyses that reference this entity

Gut-Brain Axis in Parkinson's Disease: Molecular Mechanisms, Neuroinflammation,

neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.630

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.445

Gut Microbiome Analysis in Parkinson's Disease

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.778

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.703

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.670

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Chrysophanol Attenuates Cognitive Impairment, Neuroinflammation, and Oxidative S [PMID:40728692]	Khan JZ, Zainab SR, Alattar A	Neurochem Res	2025
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR [PMID:38184025]	Unknown	Journal of ethnopharmacology	2024
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microgl [PMID:37466915]	Sun W, Wang Q, Zhang R, Zhang N	Food & function	2023
NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via [PMID:37137264]	Ibrahim Weam W; Skalicka-Woźniak K	International immunopharmacolo	2023
Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061]	Choi I, Zhang Y, Seegobin SP	Nat Commun	2020
Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction throug [PMID:32622362]	Mondal A, Bose D, Saha P	J Neuroinflammation	2020
RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammat [PMID:30884890]	["Muhammad T", "Ikram M", "Ullah R", "Re	Nutrients	2019

Debates (15)

Multi-agent debates referencing this entity

Debate: TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation

closed · Rounds: 4 · Score: 0.59 · 2026-04-27

Hypothesis debate: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes

closed · Rounds: 4 · Score: 0.60 · 2026-04-26

Hypothesis debate: Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propag

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: Enteric Nervous System Dysfunction as Self-Reinforcing Pathol

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

What are the key molecular mechanisms by which gut microbiome dysbiosis drives n

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

While single-cell sequencing reveals microglial heterogeneity across regions, ag

closed · Rounds: 4 · Score: 0.73 · 2026-04-22

The study shows P2RY12 regulates VSMC foam cell formation but doesn't explain wh

closed · Rounds: 4 · Score: 0.66 · 2026-04-21

How does the gut microbiome composition differ between PD patients and healthy c

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

The debate revealed conflicting therapeutic approaches - enhancing DNA repair ve

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

Related Research

Hypotheses and analyses mentioning NF-κB SIGNALING in their description or question text

No additional research found

NF-κB SIGNALING

Understanding Entity Pages

Pathway Diagram

Outgoing (15)

Incoming (34)

Targeting Hypotheses (1)

Mentioning Analyses (8)

Gut-Brain Axis in Parkinson's Disease: Molecular Mechanisms, Neuroinflammation,

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

Gut Microbiome Analysis in Parkinson's Disease

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

What is the temporal sequence of TREM2 signaling transition from protective to i

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

What determines P2RY12 receptor expression/activity specifically in VSMCs during

How do regional, age, and sex-dependent differences in microglial populations af

Experiments (0)

Related Papers (7)

Debates (15)

Debate: TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation

Hypothesis debate: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes

Hypothesis debate: Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propag

Hypothesis debate: Enteric Nervous System Dysfunction as Self-Reinforcing Pathol

Hypothesis debate: LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target

What are the key molecular mechanisms by which gut microbiome dysbiosis drives n

While single-cell sequencing reveals microglial heterogeneity across regions, ag

The study shows P2RY12 regulates VSMC foam cell formation but doesn't explain wh

How does the gut microbiome composition differ between PD patients and healthy c

The debate revealed conflicting therapeutic approaches - enhancing DNA repair ve

Related Research