gene

ZBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

405Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ZBP1 is a cytosolic nucleic acid sensor that activates innate immunity and regulated cell death pathways (necroptosis, PANoptosis) in neurodegenerative diseases including AD, PD, ALS, and FTD

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🧬 Gene Info

Gene Symbol	ZBP1
Aliases	DAI, DLM-1, CMTM4
Chromosome	6p24.1
Function	is a cytosolic nucleic acid sensor that plays critical roles in innate immune responses, regulated cell death pathways, and inflammation[@takaoka2007; @kuriakose2023].
Molecular Weight	46 kDa
Amino Acids	429 aa
Pathways	Apoptosis, Autophagy, Complement, Epigenetic, Immune Response
UniProt ID	Q9H171
NCBI Gene ID	23073
Ensembl ID	ENSG00000185730
GeneCards	ZBP1
Human Protein Atlas	ZBP1
Official Name	Z-DNA Binding Protein 1
Transcript Length	~3.8 kb
Protein Length	429 amino acids (full-length human isoform)
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, Atherosclerosis, Inflammation
Interactions	MFN2, GSDMD, RIPK1, RAB7A, CAT, MLKL
KG Connections	405 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ZBP1 — AlphaFold Q9H171 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ZBP1["ZBP1"]
    ZBP1 -->|"activates"| INFLAMMATION["INFLAMMATION"]
    ZBP1 -->|"activates"| APOPTOSIS["APOPTOSIS"]
    ZBP1 -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    ZBP1 -->|"interacts"| Z_DNA["Z-DNA"]
    ZBP1 -->|"activates"| Inflammation["Inflammation"]
    ZBP1 -->|"activates"| Ms["Ms"]
    ZBP1 -->|"inhibits"| Tumor["Tumor"]
    ZBP1 -->|"activates"| Als["Als"]
    ZBP1 -->|"regulates"| Cancer["Cancer"]
    BAX["BAX"] -->|"activates"| ZBP1
    DRP1["DRP1"] -->|"activates"| ZBP1
    FADD["FADD"] -->|"activates"| ZBP1
    NRF2["NRF2"] -->|"activates"| ZBP1
    ABCG2["ABCG2"] -->|"activates"| ZBP1
    TNF["TNF"] -->|"inhibits"| ZBP1
    RAB7A["RAB7A"] -->|"activates"| ZBP1
    CYTOKINES["CYTOKINES"] -->|"activates"| ZBP1
    MFN2["MFN2"] -->|"activates"| ZBP1
    GSDMD["GSDMD"] -->|"activates"| ZBP1

Outgoing (254)

Target	Relation	Type	Str
acute lung injury	promotes	disease	0.95
type I interferon response	promotes	process	0.95
PANoptosis	promotes	process	0.95
Type I Interferon Response	activates	process	0.95
TAK1-NF-κB signaling	activates	pathway	0.95
chondrocyte inflammation	promotes	process	0.95
osteoarthritis	risk_factor_for	disease	0.95
Steatotic Liver Ischemia/Reperfusion Injury	mediates	disease	0.95
Steatotic Liver Ischemia/Reperfusion Injury	contributes_to	disease	0.95
Panoptosis	activates	process	0.95
Cell Death	promotes	process	0.95
PANoptosome	component_of	structure	0.95
NF-κB	activates	pathway	0.95
Innate Immunity	associated_with	process	0.95
Inflammation	promotes	process	0.95
Steatotic Liver Ischemia/Reperfusion Injury	risk_factor_for	disease	0.92
IL-6	inhibits	protein	0.92
TBK1	interacts_with	protein	0.90
RIPK1	interacts_with	protein	0.90
toll like receptor 9 signaling	inhibits	pathway	0.90
IRF3	interacts_with	protein	0.90
NF-κB Signaling	activates	pathway	0.90
PANoptosis	mediates	process	0.90
PANoptosis	regulates	process	0.90
PANoptosis	activates	process	0.90
Zα Domain	interacts_with	mechanism	0.90
inflammatory cell death	orchestrates	process	0.90
AIM2	interacts_with	protein	0.85
NF-κB	inhibits	protein	0.85
cardiac remodeling	protects_against	process	0.82
Alzheimer's disease	causes	disease	0.80
necroptosis	participates_in	pathway	0.80
Inflammation	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Infection	activates	disease	0.75
RIPK1	activates	gene	0.70
Z-DNA	interacts_with	process	0.70
Apoptosis	activates	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
Immune Response	activates	pathway	0.70
Necroptosis	activates	pathway	0.70
Inflammasome	activates	pathway	0.70
Pyroptosis	activates	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Necroptosis	therapeutic_target	pathway	0.70
Pyroptosis	therapeutic_target	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
necroptosis	activates	process	0.70
Ms	activates	disease	0.65

Incoming (151)

Source	Relation	Type	Str
CIRP	interacts_with	protein	0.95
CIRP	prevents	protein	0.95
ZBP1-S	inhibits	protein	0.95
TNF-α	activates	protein	0.95
mtDNA release	activates	process	0.90
IRF1	regulates	protein	0.90
JNK	upregulates	gene	0.90
CIRP	binds	protein	0.90
JNK	activates	protein	0.88
reactive oxygen species	activates	process	0.85
Interferon	upregulates	process	0.85
RNA	activates	gene	0.80
RIPK3	interacts_with	gene	0.70
RIPK3	activates	gene	0.70
RIPK3	inhibits	gene	0.70
INFLAMMATION	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
PYROPTOSIS	activates	gene	0.70
PYROPTOSIS	therapeutic_target	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
DNA	regulates	gene	0.70
BAX	activates	gene	0.60
DRP1	activates	gene	0.60
FADD	activates	gene	0.60
NRF2	activates	gene	0.60
ABCG2	activates	gene	0.60
TNF	inhibits	gene	0.60
RAB7A	activates	gene	0.60
MFN2	activates	gene	0.60
GSDMD	activates	gene	0.60
CAT	activates	gene	0.60
RIPK1	activates	gene	0.60
CD4	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
FAS	activates	gene	0.60
TNF	activates	gene	0.60
IL33	activates	gene	0.60
AIM2	interacts_with	gene	0.60
TLR4	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
CASP8	activates	gene	0.60
TRIM32	interacts_with	gene	0.60
RIPK1	regulates	gene	0.60
MLKL	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
CASP8	therapeutic_target	gene	0.60
GSDMD	therapeutic_target	gene	0.60
RIPK1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ZBP1

Understanding Entity Pages

Summary

Wiki Pages (21)

ZBP1 (Z-DNA Binding Protein 1)

RNA Metabolism Dysregulation in Alzheimer's Disease

Necroptotic Neurons

Necroptosis Pathway in Neurodegeneration

DNA Sensing Pathways in Neurodegeneration

Regulated Necrosis Hypothesis in Parkinson's Disease

RNA Stability and Decay

Necroptosis in Alzheimer's Disease

Protein Synthesis in Neurodegenerative Diseases

RNA Processing in Neurodegeneration

KIF3B — Kinesin Family Member 3B

RIPK3 Protein

Stress Granules and RNA Granules in Neurodegeneration

Necroptosis in Neurodegeneration

RNA Metabolism in Alzheimer's Disease

RNA Granule Dysfunction in Neurodegeneration

RIPK1 Gene

RIPK3 Protein (Receptor-Interacting Serine/Threonine Kinase 3)

AIM2 Gene