Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TAB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive coverage of TAB1 in TAK1 complex formation, NF-κB signaling, MAPK pathways, neuroinflammation, and implications for Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.
| Gene Symbol | TAB1 |
| Full Name | TAK1-Binding Protein 1 |
| Chromosome | 11q13.1 |
| Protein Type | Adaptor Protein |
| Function | is an adaptor protein that forms a critical complex with TAK1 (Transforming Growth Factor Beta-Activated Kinase 1). |
| Subcellular Localization | both cytoplasm and nucleus |
| Molecular Weight | 110 kDa |
| Amino Acids | 504 aa |
| Pathways | NF-κB, MAPK, TGF-β, MAPK pathway, MAPK signaling |
| UniProt ID | Q61240 |
| NCBI Gene ID | 10454 |
| Ensembl ID | ENSG00000100994 |
| OMIM | 602475 |
| GeneCards | TAB1 |
| Human Protein Atlas | TAB1 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | CYTOKINES, IL-6, PROINFLAMMATORY CYTOKINES, INFLAMMATION, IL1B, MAPK14 |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TAB1["<b>TAB1</b>"]
IL1B["IL1B"]
TAB1 -->|"activates"| IL1B
MAPK14["MAPK14"]
TAB1 -->|"activates"| MAPK14
TRAF6["TRAF6"]
TAB1 -->|"binds"| TRAF6
MAPK3["MAPK3"]
TAB1 -->|"activates"| MAPK3
MAPK1["MAPK1"]
TAB1 -->|"activates"| MAPK1
neurodegeneration["neurodegeneration"]
TAB1 -->|"implicated in"| neurodegeneration
style TAB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| NF-κB signaling | upstream_of | pathway | 0.92 |
| IL1B | activates | protein | 0.80 |
| MAPK14 | activates | protein | 0.70 |
| TRAF6 | binds | protein | 0.70 |
| Als | expressed_in | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Diabetes | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Cardiovascular | activates | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| RELA | expressed_in | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| IL-6 | activates | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| PROINFLAMMATORY CYTOKINES | activates | gene | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| Microrna | activates | pathway | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| Mapk | activates | pathway | 0.60 |
| MAPK3 | activates | protein | 0.60 |
| MAPK1 | activates | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TRIM21 | interacts_with | protein | 0.95 |
| NLRP6 | facilitates_degradation_via_TRIM21 | protein | 0.93 |
| IRAK4 | expressed_in | gene | 0.60 |
| P38 | inhibits | gene | 0.60 |
| MAPK | activates | gene | 0.60 |
| VIRAL INFECTIONS | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| AND | causes | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||