gene

NGFR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NGFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections
0Hypotheses
0Analyses
20Outgoing
21Incoming

Summary

NGFR is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Inflammation, Ms, Schizophrenia. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNGFR
Full NameNerve Growth Factor Receptor
Chromosome17q21.33
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysNF-κB
UniProt IDP08151
NCBI Gene ID4800
Ensembl IDENSG00000164329
OMIM162010
GeneCardsNGFR
Human Protein AtlasNGFR
Survival signalingWhen co-expressed with Trk receptors, p75NTR enhances Trk signaling through:
Cell death signalingIn the absence of Trk receptors or when overexpressed, p75NTR can activate:
Associated DiseasesAlzheimer, Neuropathy
InteractionsNTF4, ABCA7, ALZHEIMER'S DISEASE, ALZHEIMER, NTRK2, SRC
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NGFR — AlphaFold P08151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NGFR Gene

gene · 924 words

NTF4 Protein

protein · 5111 words

Neurotrophin Signaling Pathways in Neurodegeneration

mechanism · 4695 words

p75NTR Protein

protein · 2886 words

NTF5 — Neurotrophin 5

gene · 2681 words

Cholinergic System Dysfunction in Neurodegeneration

mechanism · 2382 words

Pathway Diagram

graph TD
    NGFR["<b>NGFR</b>"]
    Ms{"Ms"}
    NGFR -->|"interacts with"| Ms
    Inflammation{"Inflammation"}
    NGFR -->|"interacts with"| Inflammation
    Schizophrenia{"Schizophrenia"}
    NGFR -->|"interacts with"| Schizophrenia
    NTF4["NTF4"]
    NGFR -->|"interacts with"| NTF4
    Immune_Response(["Immune Response"])
    NGFR -->|"interacts with"| Immune_Response
    neurodegeneration["neurodegeneration"]
    NGFR -->|"implicated in"| neurodegeneration
    NTRK2["NTRK2"]
    NTRK2 -->|"interacts with"| NGFR
    SRC["SRC"]
    SRC -->|"interacts with"| NGFR
    CTNNB1["CTNNB1"]
    CTNNB1 -->|"interacts with"| NGFR
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"interacts with"| NGFR
    STAT3["STAT3"]
    STAT3 -->|"interacts with"| NGFR
    TRAF6["TRAF6"]
    TRAF6 -->|"interacts with"| NGFR
    BDNF["BDNF"]
    BDNF -->|"interacts with"| NGFR
    DISC1["DISC1"]
    DISC1 -->|"interacts with"| NGFR
    NEUROTOXICITY["NEUROTOXICITY"]
    NEUROTOXICITY -->|"interacts with"| NGFR
    CDH1["CDH1"]
    CDH1 -->|"interacts with"| NGFR
    style NGFR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

TargetRelationTypeStr
Msinteracts_withdisease0.65
Inflammationinteracts_withdisease0.65
Schizophreniainteracts_withdisease0.65
Neuropathyassociated_withdisease0.65
Alzheimeractivatesdisease0.65

Incoming (21)

SourceRelationTypeStr
NTRK2interacts_withgene0.60
SRCinteracts_withgene0.60
CTNNB1interacts_withgene0.60
STAT3interacts_withgene0.60
TRAF6interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found