Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NGFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NGFR is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Inflammation, Ms, Schizophrenia. Connected to 16 entities in the SciDEX knowledge graph.
| Gene Symbol | NGFR |
| Full Name | Nerve Growth Factor Receptor |
| Chromosome | 17q21.33 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | NF-κB |
| UniProt ID | P08151 |
| NCBI Gene ID | 4800 |
| Ensembl ID | ENSG00000164329 |
| OMIM | 162010 |
| GeneCards | NGFR |
| Human Protein Atlas | NGFR |
| Survival signaling | When co-expressed with Trk receptors, p75NTR enhances Trk signaling through: |
| Cell death signaling | In the absence of Trk receptors or when overexpressed, p75NTR can activate: |
| Associated Diseases | Alzheimer, Neuropathy |
| Interactions | NTF4, ABCA7, ALZHEIMER'S DISEASE, ALZHEIMER, NTRK2, SRC |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NGFR["<b>NGFR</b>"]
Ms{"Ms"}
NGFR -->|"interacts with"| Ms
Inflammation{"Inflammation"}
NGFR -->|"interacts with"| Inflammation
Schizophrenia{"Schizophrenia"}
NGFR -->|"interacts with"| Schizophrenia
NTF4["NTF4"]
NGFR -->|"interacts with"| NTF4
Immune_Response(["Immune Response"])
NGFR -->|"interacts with"| Immune_Response
neurodegeneration["neurodegeneration"]
NGFR -->|"implicated in"| neurodegeneration
NTRK2["NTRK2"]
NTRK2 -->|"interacts with"| NGFR
SRC["SRC"]
SRC -->|"interacts with"| NGFR
CTNNB1["CTNNB1"]
CTNNB1 -->|"interacts with"| NGFR
CYTOKINES["CYTOKINES"]
CYTOKINES -->|"interacts with"| NGFR
STAT3["STAT3"]
STAT3 -->|"interacts with"| NGFR
TRAF6["TRAF6"]
TRAF6 -->|"interacts with"| NGFR
BDNF["BDNF"]
BDNF -->|"interacts with"| NGFR
DISC1["DISC1"]
DISC1 -->|"interacts with"| NGFR
NEUROTOXICITY["NEUROTOXICITY"]
NEUROTOXICITY -->|"interacts with"| NGFR
CDH1["CDH1"]
CDH1 -->|"interacts with"| NGFR
style NGFR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | interacts_with | disease | 0.65 |
| Inflammation | interacts_with | disease | 0.65 |
| Schizophrenia | interacts_with | disease | 0.65 |
| Neuropathy | associated_with | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| NTF4 | interacts_with | gene | 0.60 |
| CCT5 | expressed_in | gene | 0.60 |
| ABCA7 | activates | gene | 0.60 |
| RAB7 | associated_with | gene | 0.60 |
| SPTLC1 | associated_with | gene | 0.60 |
| Immune Response | interacts_with | pathway | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| Ngf | expressed_in | protein | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| ALZHEIMER | activates | gene | 0.50 |
| Alzheimer'S Disease | activates | disease | 0.50 |
| disease | activates | disease | 0.50 |
| ALZHEIMER'S | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NTRK2 | interacts_with | gene | 0.60 |
| SRC | interacts_with | gene | 0.60 |
| CTNNB1 | interacts_with | gene | 0.60 |
| STAT3 | interacts_with | gene | 0.60 |
| TRAF6 | interacts_with | gene | 0.60 |
| BDNF | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| CCT5 | expressed_in | gene | 0.60 |
| SPTLC1 | associated_with | gene | 0.60 |
| RAB7 | associated_with | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| CYTOKINES | interacts_with | gene | 0.60 |
| NEUROTOXICITY | interacts_with | gene | 0.60 |
| CDH1 | interacts_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| ABCA7 | activates | gene | 0.50 |
| ABCA7 | co_expressed_with | gene | 0.50 |
| BDNF | co_expressed_with | gene | 0.50 |
| BDNF | co_mentioned | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||