gene

NGFR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NGFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

1Analyses

23Outgoing

19Incoming

0Experiments

1Debates

Summary

NGFR is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Inflammation, Ms, Schizophrenia. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NGFR
Full Name	Nerve Growth Factor Receptor
Chromosome	17q21.33
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Pathways	NF-κB
UniProt ID	P08151
NCBI Gene ID	4800
Ensembl ID	ENSG00000164329
OMIM	162010
GeneCards	NGFR
Human Protein Atlas	NGFR
Survival signaling	When co-expressed with Trk receptors, p75NTR enhances Trk signaling through:
Cell death signaling	In the absence of Trk receptors or when overexpressed, p75NTR can activate:
Associated Diseases	A1 astrocyte phenotype, Alzheimer, Neuropathy
Interactions	ABCA7, ALZHEIMER, ALZHEIMER'S DISEASE, BDNF, CDH1, CTNNB1
KG Connections	42 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NGFR — AlphaFold P08151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NGFR Gene

gene · 924 words

→

NGFR (p75NTR) Protein

protein · 609 words

→

Pathway Diagram

graph TD
    NGFR["NGFR"]
    Ms{"Ms"}
    NGFR -->|"interacts with"| Ms
    Inflammation{"Inflammation"}
    NGFR -->|"interacts with"| Inflammation
    Schizophrenia{"Schizophrenia"}
    NGFR -->|"interacts with"| Schizophrenia
    NTF4["NTF4"]
    NGFR -->|"interacts with"| NTF4
    Immune_Response(["Immune Response"])
    NGFR -->|"interacts with"| Immune_Response
    neurodegeneration["neurodegeneration"]
    NGFR -->|"implicated in"| neurodegeneration
    NTRK2["NTRK2"]
    NTRK2 -->|"interacts with"| NGFR
    SRC["SRC"]
    SRC -->|"interacts with"| NGFR
    CTNNB1["CTNNB1"]
    CTNNB1 -->|"interacts with"| NGFR
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"interacts with"| NGFR
    STAT3["STAT3"]
    STAT3 -->|"interacts with"| NGFR
    TRAF6["TRAF6"]
    TRAF6 -->|"interacts with"| NGFR
    BDNF["BDNF"]
    BDNF -->|"interacts with"| NGFR
    DISC1["DISC1"]
    DISC1 -->|"interacts with"| NGFR
    NEUROTOXICITY["NEUROTOXICITY"]
    NEUROTOXICITY -->|"interacts with"| NGFR
    CDH1["CDH1"]
    CDH1 -->|"interacts with"| NGFR
    style NGFR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (23)

Target	Relation	Type	Str
ROCK2	activates	protein	0.70
NFKB1	activates	protein	0.70
A1 astrocyte phenotype	associated_with	phenotype	0.70
Inflammation	interacts_with	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
Neuropathy	associated_with	disease	0.65
Ngf	expressed_in	protein	0.60
Immune Response	interacts_with	pathway	0.60
Alzheimer	associated_with	disease	0.60
RAB7	associated_with	gene	0.60
SPTLC1	associated_with	gene	0.60
CCT5	expressed_in	gene	0.60
NTF4	interacts_with	gene	0.60
ABCA7	activates	gene	0.60
Neuron	associated_with	cell_type	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
Neuron	expressed_in	cell_type	0.55
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
ALZHEIMER	activates	gene	0.50

Incoming (19)

Source	Relation	Type	Str
CCT5	expressed_in	gene	0.60
SPTLC1	associated_with	gene	0.60
RAB7	associated_with	gene	0.60
GENES	associated_with	gene	0.60
NTRK2	interacts_with	gene	0.60
SRC	interacts_with	gene	0.60
CTNNB1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
TRAF6	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
BDNF	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
BDNF	interacts_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
NEUROTOXICITY	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
ABCA7	co_expressed_with	gene	0.50
ABCA7	activates	gene	0.50
BDNF	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.651

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract describes astrocyte phenotypic heterogeneity (A1/A2) but doesn't ex

closed · Rounds: 4 · Score: 0.66 · 2026-04-15

Related Research

Hypotheses and analyses mentioning NGFR in their description or question text

No additional research found