gene

ROCK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ROCK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

1Analyses

50Outgoing

28Incoming

0Experiments

1Debates

Summary

Comprehensive coverage of ROCK2 (Rho-associated protein kinase 2) in cytoskeletal dynamics, synaptic function, and neurodegenerative diseases including AD/PD.

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🧬 Gene Info

Gene Symbol	ROCK2
Full Name	Rho-associated Protein Kinase 2
Chromosome	2p24.1
Protein Type	Serine/Threonine Kinase
Function	encodes a serine/threonine kinase that functions as a major effector of the small GTPase RhoA.
Primary Expression	Ubiquitous, highest in testis
Subcellular Localization	Cytoplasmic, membrane
Molecular Weight	160 kDa
Amino Acids	388 aa
Exons	33
Pathways	Glycolysis
GeneCards	ROCK2
Human Protein Atlas	ROCK2
Associated Diseases	Huntington, neurodegeneration
Interactions	AKT, AND, APOPTOSIS, BRAIN INJURY, CALB2, CANCER
KG Connections	91 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ROCK2 Gene

gene · 2944 words

→

ROCK2 Protein

protein · 655 words

→

Pathway Diagram

graph TD
    ROCK2["ROCK2"]
    Carcinoma{"Carcinoma"}
    ROCK2 -->|"activates"| Carcinoma
    Als{"Als"}
    ROCK2 -->|"regulates"| Als
    Cancer{"Cancer"}
    ROCK2 -->|"activates"| Cancer
    Tumor{"Tumor"}
    ROCK2 -->|"regulates"| Tumor
    HK2["HK2"]
    ROCK2 -->|"regulates"| HK2
    Glycolysis(["Glycolysis"])
    ROCK2 -->|"regulates"| Glycolysis
    neurodegeneration["neurodegeneration"]
    ROCK2 -->|"implicated in"| neurodegeneration
    CANCER["CANCER"]
    CANCER -->|"activates"| ROCK2
    style ROCK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (63)

Target	Relation	Type	Str
neuroprotective gene expression	inhibits	process	0.70
CREB1	inhibits	protein	0.70
Carcinoma	activates	disease	0.65
Ataxia	regulates	disease	0.65
Spinocerebellar Ataxia	regulates	disease	0.65
Huntington	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
PI3K	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60
neurodegeneration	activates	disease	0.60
BRAIN INJURY	activates	gene	0.60
NEURON	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ROS	activates	gene	0.60
STROKE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mtor	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Akt	activates	pathway	0.60
Amyloid	biomarker_for	pathway	0.60
AGING	biomarker_for	gene	0.60
GJA1	activates	gene	0.60
Aβ	biomarker_for	protein	0.60
AKT	biomarker_for	gene	0.60
GNA13	activates	gene	0.60
DNAJC6	regulates	gene	0.60
neurodegeneration	associated_with	disease	0.60
App	regulates	protein	0.60
AND	activates	gene	0.60
PTEN	activates	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
MAPK	biomarker_for	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
RNA	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
Huntington	associated_with	disease	0.60
HK2	regulates	gene	0.60

Incoming (28)

Source	Relation	Type	Str
GNA13	interacts_with	gene	0.80
NGFR	activates	gene	0.70
ROCK1	activates	gene	0.60
CANCER	activates	gene	0.60
EXOSOMES	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
GNA13	activates	gene	0.60
TAU	biomarker_for	gene	0.60
GJA1	activates	gene	0.60
ROCK1	biomarker_for	gene	0.60
AKT	activates	gene	0.60
PTEN	activates	gene	0.60
ROCK	activates	gene	0.60
HUNTINGTON	regulates	gene	0.60
GNA13	associated_with	gene	0.60
SYNAPSE	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GJA1	associated_with	gene	0.60
DNAJC6	regulates	gene	0.60
CALB2	activates	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
RNA	biomarker_for	gene	0.60
MAPK	biomarker_for	gene	0.60
AGING	biomarker_for	gene	0.60
DNAJC5	co_expressed_with	gene	0.50
DNAJC5	activates	gene	0.50
DNAJC6	co_expressed_with	gene	0.50
Neurodegeneration	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.651

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract describes astrocyte phenotypic heterogeneity (A1/A2) but doesn't ex

closed · Rounds: 4 · Score: 0.66 · 2026-04-15

Related Research

Hypotheses and analyses mentioning ROCK2 in their description or question text

No additional research found