gene

ROCK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ROCK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

Summary

Comprehensive coverage of ROCK2 (Rho-associated protein kinase 2) in cytoskeletal dynamics, synaptic function, and neurodegenerative diseases including AD/PD.

View on Wiki →

🧬 Gene Info

Gene Symbol	ROCK2
Full Name	Rho-associated Protein Kinase 2
Chromosome	2p24.1
Protein Type	Serine/Threonine Kinase
Function	encodes a serine/threonine kinase that functions as a major effector of the small GTPase RhoA.
Primary Expression	Ubiquitous, highest in testis
Subcellular Localization	Cytoplasmic, membrane
Molecular Weight	160 kDa
Amino Acids	388 aa
Exons	33
Pathways	Glycolysis
GeneCards	ROCK2
Human Protein Atlas	ROCK2
Feature	ROCK1
Tissue expression	Ubiquitous, highest in testis
Associated Diseases	Huntington, neurodegeneration
Interactions	PTEN, MTOR, AKT, GJA1, GNA13, CALB2
KG Connections	88 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ROCK2["<b>ROCK2</b>"]
    Carcinoma{"Carcinoma"}
    ROCK2 -->|"activates"| Carcinoma
    Als{"Als"}
    ROCK2 -->|"regulates"| Als
    Cancer{"Cancer"}
    ROCK2 -->|"activates"| Cancer
    Tumor{"Tumor"}
    ROCK2 -->|"regulates"| Tumor
    HK2["HK2"]
    ROCK2 -->|"regulates"| HK2
    Glycolysis(["Glycolysis"])
    ROCK2 -->|"regulates"| Glycolysis
    neurodegeneration["neurodegeneration"]
    ROCK2 -->|"implicated in"| neurodegeneration
    CANCER["CANCER"]
    CANCER -->|"activates"| ROCK2
    style ROCK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (61)

Target	Relation	Type	Str
Carcinoma	activates	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
Als	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Stroke	activates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Huntington	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	regulates	disease	0.65
Spinocerebellar Ataxia	regulates	disease	0.65
HK2	regulates	gene	0.60
PTEN	activates	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
GJA1	activates	gene	0.60
AKT	biomarker_for	gene	0.60
GNA13	activates	gene	0.60
PI3K	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60
CALB2	activates	gene	0.60
DNAJC5	activates	gene	0.60
DNAJC6	regulates	gene	0.60
Rb	regulates	protein	0.60
neurodegeneration	activates	disease	0.60
neurodegeneration	associated_with	disease	0.60
Glycolysis	regulates	pathway	0.60
BRAIN INJURY	activates	gene	0.60
AND	activates	gene	0.60
NEURON	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ROS	activates	gene	0.60
STROKE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mtor	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Akt	activates	pathway	0.60
Mapk	biomarker_for	pathway	0.60
Neuron	regulates	cell_type	0.60
ALZHEIMER	biomarker_for	gene	0.60
MAPK	biomarker_for	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
RNA	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
Amyloid	biomarker_for	pathway	0.60

Incoming (27)

Source	Relation	Type	Str
GNA13	interacts_with	gene	0.80
ROCK1	activates	gene	0.60
GNA13	activates	gene	0.60
TAU	biomarker_for	gene	0.60
GJA1	activates	gene	0.60
CALB2	activates	gene	0.60
DNAJC6	regulates	gene	0.60
GJA1	associated_with	gene	0.60
GNA13	associated_with	gene	0.60
ROCK1	biomarker_for	gene	0.60
AKT	activates	gene	0.60
PTEN	activates	gene	0.60
ROCK	activates	gene	0.60
CANCER	activates	gene	0.60
EXOSOMES	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AGING	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
RNA	biomarker_for	gene	0.60
MAPK	biomarker_for	gene	0.60
HUNTINGTON	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DNAJC5	activates	gene	0.50
DNAJC5	co_expressed_with	gene	0.50
DNAJC6	co_expressed_with	gene	0.50
Neurodegeneration	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ROCK2

Understanding Entity Pages

Summary

Wiki Pages (21)

ROCK2 Gene

ROCK1 Gene

PDCD10 Gene (Programmed Cell Death 10)

rock-inhibitor-fasudil-psp-cbs-nct04734379

RHOA Gene — Ras Homolog Family Member A

rock-inhibitor-tauopathies

ARHGEF2 Protein (LARG)

Extracellular Matrix and Integrin Modulator Therapy for Neurodegeneration

ROCK Inhibitor Therapy for Neurodegeneration

Fasudil for Early Alzheimer's Disease (FEAD) - NCT06362707

RAC2 Protein

rock-inhibitor-therapy-parkinsons

ALS Trial Failure Analysis

CCM2 Gene

Fasudil for Parkinson's Disease (ROCK-PD)

ARHGEF2 Gene

RhoA Protein

ROCK2 Protein

GNA13 Gene