gene

NGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1004Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

Nerve Growth Factor - founding member of neurotrophin family for neuronal survival

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NGF
Full Name	Nerve Growth Factor
Chromosome	1p13.1
Protein Family	Neurotrophin family
Primary Expression	Primarily in nociceptive sensory neurons, cholinergic basal forebrain neurons, sympathetic ganglia
Molecular Weight	30 kDa
Amino Acids	120 aa
Exons	3
Pathways	PI3K, MAPK
UniProt ID	P01138
NCBI Gene ID	4800
Ensembl ID	ENSG00000111665
OMIM	162030
GeneCards	NGF
Human Protein Atlas	NGF
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, ANGIOGENESIS
Known Drugs/Compounds	aducanumab, lecanemab, metformin
Interactions	ACHE, Actin, ADRB2, AGING, Akt, AKT
KG Connections	763 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NGF — AlphaFold P01138 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NGF["NGF"]
    NGF -->|"downregulates"| PRDM4["PRDM4"]
    NGF -->|"activates"| Als["Als"]
    NGF -->|"expressed in"| Ischemia["Ischemia"]
    NGF -->|"activates"| Ms["Ms"]
    NGF -->|"regulates"| Inflammation["Inflammation"]
    NGF -->|"target for"| Diabetes["Diabetes"]
    NGF -->|"target for"| Neurodegeneration["Neurodegeneration"]
    CHAT["CHAT"] -->|"regulates"| NGF
    TRKA["TRKA"] -->|"interacts"| NGF
    NRP1["NRP1"] -->|"activates"| NGF
    BDNF["BDNF"] -->|"activates"| NGF
    CHR2["CHR2"] -->|"regulates"| NGF
    GFAP["GFAP"] -->|"activates"| NGF
    TNF["TNF"] -->|"regulates"| NGF
    SLC7A11["SLC7A11"] -->|"activates"| NGF
    GAIN["GAIN"] -->|"activates"| NGF
    GPX4["GPX4"] -->|"activates"| NGF

Outgoing (553)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.95
NEUROTROPHINS	component_of	protein	0.95
neurons	expressed_in	cell_type	0.90
Nervous System Development	regulates	process	0.90
Neurite Outgrowth	promotes	phenotype	0.85
ERK	activates	protein	0.85
neurotrophin signaling	participates_in	pathway	0.85
dorsal root ganglia	expressed_in	cell_type	0.85
hippocampus	expressed_in	brain_region	0.80
neurons	activates	cell_type	0.80
Hepatocellular Carcinoma	biomarker_for	disease	0.75
Als	activates	disease	0.75
Diabetes	activates	disease	0.75
Obesity	activates	disease	0.75
Als	treats	disease	0.75
Senescence	activates	disease	0.75
Inflammation	activates	disease	0.75
Lipid Metabolism	activates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
basal forebrain cholinergic neuron survival	regulates	process	0.70
oxidative stress response	participates_in	pathway	0.70
Alzheimer's disease	biomarker_for	disease	0.70
Alzheimer's disease	treats	disease	0.70
neurodegeneration	associated_with	disease	0.70
Alzheimer's disease	interacts_with	disease	0.70
neurons	associated_with	cell_type	0.70
Anxiety	activates	disease	0.65
Alzheimer	activates	disease	0.65
TAU	associated_with	gene	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neuroinflammation	treats	disease	0.65
PARP1	associated_with	gene	0.65
Aging	activates	disease	0.65
Tumor	treats	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
ALS	activates	disease	0.65
Inflammation	treats	disease	0.65
Cancer	regulates	disease	0.65
Dementia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Schizophrenia	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Depression	activates	disease	0.65
Als	interacts_with	disease	0.65
Ms	activates	disease	0.65

Incoming (451)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
BDNF	associated_with	gene	0.90
Optogenetic Stimulation	upregulates	mechanism	0.90
ChR2	upregulates	protein	0.85
FB23	upregulates	drug	0.85
NEURODEGENERATION	associated_with	concept	0.82
PARKINSON'S DISEASE	associated_with	disease	0.82
CYTOKINES	activates	gene	0.80
NEURODEGENERATION	activates	gene	0.80
BDNF	activates	gene	0.74
AMYLOID	associated_with	gene	0.74
CHAT	regulates	gene	0.70
GDNF	regulates	gene	0.70
BDNF	protects_against	gene	0.70
ALS	associated_with	disease	0.66
AKT	associated_with	gene	0.66
GDNF	associated_with	gene	0.65
NOREPINEPHRINE	activates	phenotype	0.65
ULK1	activates	gene	0.65
MAPK	inhibits	gene	0.60
HIF	activates	gene	0.60
TRKA	interacts_with	gene	0.60
PARKINSON	associated_with	gene	0.60
DEPRESSION	inhibits	gene	0.60
GENES	regulates	gene	0.60
LDL	regulates	gene	0.60
NGF	activates	gene	0.60
BDNF	activates	gene	0.60
CHR2	activates	gene	0.60
CNTN1	biomarker_for	gene	0.60
NGF	biomarker_for	gene	0.60
ERK	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
PRKN	activates	gene	0.60
PARKIN	inhibits	gene	0.60
GDNF	activates	gene	0.60
P53	activates	gene	0.60
LMX1A	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
NURR1	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
ASCL1	activates	gene	0.60
CATALASE	activates	gene	0.60
AKT	activates	gene	0.60
NRF2	activates	gene	0.60
C-JUN	activates	gene	0.60
MICROGLIA	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Basal forebrain NGF/TrkA trophic failure is an upstream trig	0.610	neurodegeneration	What determines the temporal sequence of

Mentioning Analyses (4)

Scientific analyses that reference this entity

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.730

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 16 hypotheses Top: 0.779

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.710

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.791

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

closed · Rounds: 4 · Score: 0.46 · 2026-04-27

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

closed · Rounds: 4 · Score: 0.46 · 2026-04-27

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

closed · Rounds: 4 · Score: 0.65 · 2026-04-25

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

closed · Rounds: 4 · Score: 0.83 · 2026-04-06

Epigenetic clocks and biological aging in neurodegeneration

closed · Rounds: 4 · Score: 0.93 · 2026-04-06

Related Research

Hypotheses and analyses mentioning NGF in their description or question text

No additional research found

NGF

Understanding Entity Pages

Summary

Wiki Pages (9)

PC12 Cell Line

NGF Gene

Nerve Growth Factor (NGF)

NGFR Gene

NGF Protein

NGF Neurons

NGF (Redirect)

NGFR (p75NTR) Protein

Nerve Growth Factor (NGF) Responsive Neurons

Pathway Diagram

Outgoing (553)

Incoming (451)

Targeting Hypotheses (1)

Mentioning Analyses (4)

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

Epigenetic reprogramming in aging neurons

Epigenetic clocks and biological aging in neurodegeneration

Neuroinflammation resolution mechanisms and pro-resolving mediators

Experiments (0)

Related Papers (0)

Debates (6)

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

What determines the temporal sequence of cholinergic dysfunction versus amyloid/

Epigenetic reprogramming in aging neurons

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

Epigenetic clocks and biological aging in neurodegeneration

Related Research