protein

Ngf

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Ngf: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1044Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	NGF
Full Name	Nerve Growth Factor
Chromosome	1p13.1
Protein Family	Neurotrophin family
Function	Hippocampal modulation, memory consolidation, attention, theta rhythm generation
Primary Expression	Primarily in nociceptive sensory neurons, cholinergic basal forebrain neurons, sympathetic ganglia
Molecular Weight	30 kDa
Amino Acids	120 aa
Exons	3
Pathways	PI3K, MAPK
UniProt ID	P01138
NCBI Gene ID	4800
Ensembl ID	ENSG00000111665
OMIM	162030
GeneCards	NGF
Human Protein Atlas	NGF
Associated Diseases	Als, Alzheimer, Cancer, Hypertension, Neurodegeneration, Neuropathy
Interactions	NGF, BDNF, CHR2, TRKB, GABA, EXERCISE
KG Connections	245 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: Ngf — AlphaFold P01138 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Ngf["Ngf"] -->|"therapeutic target"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ngf["Ngf"] -->|"therapeutic target"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ngf["Ngf"] -->|"contributes to"| Dementia["Dementia"]
    style Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ngf["Ngf"] -->|"activates"| Depression["Depression"]
    style Depression fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ngf["Ngf"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ngf["Ngf"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ngf["Ngf"] -->|"activates"| Epilepsy["Epilepsy"]
    style Epilepsy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    SRPK1["SRPK1"] -->|"therapeutic target"| Ngf["Ngf"]
    style SRPK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"therapeutic target"| Ngf["Ngf"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DRAK2["DRAK2"] -->|"therapeutic target"| Ngf["Ngf"]
    style DRAK2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PIEZO1["PIEZO1"] -->|"therapeutic target"| Ngf["Ngf"]
    style PIEZO1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TRPV4["TRPV4"] -->|"therapeutic target"| Ngf["Ngf"]
    style TRPV4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Ngf fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (575)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Als	activates	disease	0.60
Dementia	contributes_to	disease	0.60
Depression	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Dementia	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Epilepsy	activates	disease	0.60
Neuropathy	therapeutic_target	disease	0.60
Als	biomarker_for	disease	0.60
Diabetes	inhibits	disease	0.60
Fibrosis	inhibits	disease	0.60
Cardiomyopathy	inhibits	disease	0.60
Fibrosis	protects_against	disease	0.60
Als	causes	disease	0.60
Aging	expressed_in	disease	0.60
Schizophrenia	expressed_in	disease	0.60
Bipolar	expressed_in	disease	0.60
Als	associated_with	disease	0.60
Ptsd	associated_with	disease	0.60
Hypertension	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Cancer	associated_with	disease	0.60
Alzheimer	activates	disease	0.60
Aging	activates	disease	0.60
Parkinson	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Neuropathy	associated_with	disease	0.60
Alzheimer	regulates	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Parkinson	inhibits	disease	0.60
Als	contributes_to	disease	0.60
Epilepsy	encodes	disease	0.60
Aging	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Als	inhibits	disease	0.60
Neuropathy	regulates	disease	0.60
Als	regulates	disease	0.60
Alzheimer	protects_against	disease	0.60
Als	protects_against	disease	0.60
Aging	biomarker_for	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Huntington	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Diabetes	activates	disease	0.60
Opioid	therapeutic_target	disease	0.60
Chronic Pain	inhibits	disease	0.60

Incoming (469)

Source	Relation	Type	Str
SRPK1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
DRAK2	therapeutic_target	gene	0.60
PIEZO1	therapeutic_target	gene	0.60
TRPV4	therapeutic_target	gene	0.60
NGF	activates	gene	0.60
BDNF	activates	gene	0.60
CHR2	activates	gene	0.60
CNTN1	biomarker_for	gene	0.60
NGF	biomarker_for	gene	0.60
ERK	therapeutic_target	gene	0.60
DEMENTIA	contributes_to	gene	0.60
TRKB	activates	gene	0.60
GABA	activates	gene	0.60
EXERCISE	activates	gene	0.60
IGF-1	activates	gene	0.60
NPY	activates	gene	0.60
DEPRESSION	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-1	activates	gene	0.60
IL-6	activates	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MET	activates	gene	0.60
EPILEPSY	activates	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
CATALASE	biomarker_for	gene	0.60
CCND1	inhibits	gene	0.60
ERK	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CYP1A1	inhibits	gene	0.60
ROS	inhibits	gene	0.60
SLC2A1	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
NOX4	inhibits	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
FLOT1	expressed_in	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CRH	associated_with	gene	0.60
AVP	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
POMC	associated_with	gene	0.60
DNA	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Ngf

Understanding Entity Pages

Wiki Pages (21)

Medial Septal Cholinergic Projection

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

CBS/PSP Supplements Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Neuroresilience Mechanisms and Evidence

CBS/PSP Treatment Rankings

nct07165106

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

Growth Factor Therapies

Neurotrophin Signaling Pathways in Neurodegeneration

dendritic-spines

Vitamin D Signaling Pathway in Neurodegeneration

vitamin-d-therapy-neurodegeneration

MACF1 — Microtubule-actin crosslinking factor 1

Novartis Alzheimer's Disease Phase 2 Trial (NCT07094516)

Growth Factor Therapeutics: Investment Landscape Analysis

IGF-1 Signaling Pathway in Neurodegeneration

Pedunculopontine Nucleus Cholinergic Neurons in Neurodegeneration