NLGN3

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLGN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NLGN3 encodes neuroligin-3, a postsynaptic cell adhesion molecule critical for synapse formation, function, and plasticity. Mutations cause autism spectrum disorder and intellectual disability, and altered NLGN3 is implicated in Alzheimer's and Parkinson's disease synaptic dysfunction.

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graph TD
    NLGN3["<b>NLGN3</b>"]
    synapse["synapse"]
    NLGN3 -->|"regulates"| synapse
    excitatory_synaptic_transmission["excitatory synaptic transmission"]
    NLGN3 -->|"regulates"| excitatory_synaptic_transmission
    PI3K_mTOR(["PI3K-mTOR"])
    NLGN3 -->|"activates"| PI3K_mTOR
    glioblastoma{"glioblastoma"}
    NLGN3 -->|"activates"| glioblastoma
    FAK["FAK"]
    NLGN3 -->|"activates"| FAK
    PI3K_mTOR_pathway(["PI3K-mTOR pathway"])
    NLGN3 -->|"activates"| PI3K_mTOR_pathway
    high_grade_gliomas{"high-grade gliomas"}
    NLGN3 -->|"associated with"| high_grade_gliomas
    neurodegeneration["neurodegeneration"]
    NLGN3 -->|"implicated in"| neurodegeneration
    neuronal_activity(["neuronal activity"])
    neuronal_activity -->|"regulates"| NLGN3
    ADAM10["ADAM10"]
    ADAM10 -->|"activates"| NLGN3
    ADAM10 -->|"regulates"| NLGN3
    neuronal_activity -->|"activates"| NLGN3
    ADAM10_inhibitors["ADAM10 inhibitors"]
    ADAM10_inhibitors -->|"protects against"| NLGN3
    style NLGN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0