concept

ISCHEMIC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISCHEMIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

416Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

ISCHEMIC is a concept in neurodegeneration research. Key relationships include: co discussed, protects against, activates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 100 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ISCHEMIC
Key Genes/Proteins	NLRP3, NRF2, LRP1, IL-6
Related Diseases	STROKE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ISCHEMIC["<b>ISCHEMIC</b>"]
    ISCHEMIC -->|"treats"| STROKE["STROKE"]
    ISCHEMIC -->|"activates"| MMP2["MMP2"]
    ISCHEMIC -->|"activates"| MMP9["MMP9"]
    ISCHEMIC -->|"activates"| MICROGLIA["MICROGLIA"]
    ISCHEMIC -.protects against.-> NEURON["NEURON"]
    ISCHEMIC -.protects against.-> NEURONS["NEURONS"]
    ISCHEMIC -->|"activates"| RIPK1["RIPK1"]
    ISCHEMIA["ISCHEMIA"] -->|"causes"| ISCHEMIC
    CELL_DEATH["CELL DEATH"] -->|"causes"| ISCHEMIC
    AMPK["AMPK"] -.protects against.-> ISCHEMIC
    AUTOPHAGY["AUTOPHAGY"] -->|"inhibits"| ISCHEMIC
    APOPTOSIS["APOPTOSIS"] -->|"promotes"| ISCHEMIC
    ATG7["ATG7"] -.protects against.-> ISCHEMIC
    BCL2["BCL2"] -.protects against.-> ISCHEMIC
    INFLAMMATION["INFLAMMATION"] -->|"impairs"| ISCHEMIC
    IL6["IL6"] -->|"inhibits"| ISCHEMIC
    DEMENTIA["DEMENTIA"] -->|"causes"| ISCHEMIC

Outgoing (136)

Target	Relation	Type	Str
NLRP3	regulates	gene	0.65
STROKE	exacerbates	disease	0.65
MICROGLIA	promotes	cell_type	0.65
NRF2	promotes	gene	0.65
MACROPHAGE	targets	cell_type	0.65
MACROPHAGES	targets	cell_type	0.65
STROKE	increases	disease	0.65
WHITE MATTER	causes	brain_region	0.65
STROKE	interacts_with	disease	0.65
LRP1	mediates	gene	0.65
NRF2	inhibits	gene	0.65
MICROGLIA	causes	cell_type	0.65
STROKE	treats	disease	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
STROKE	activates	disease	0.60
MICROGLIA	activates	cell_type	0.60
MICROGLIA	targets	cell_type	0.60
MICROGLIA	protects_against	cell_type	0.60
MICROGLIA	expressed_in	cell_type	0.60
MICROGLIA	regulates	cell_type	0.60
NEURON	protects_against	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
RIPK1	activates	gene	0.60
PARKIN	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
MICROGLIA	interacts_with	cell_type	0.60
NEURON	interacts_with	cell_type	0.60
NEURONS	interacts_with	cell_type	0.60
STROKE	targets	disease	0.60
WHITE MATTER	treats	brain_region	0.60
STROKE	causes	disease	0.60
RIPK1	treats	gene	0.60
RIPK3	treats	gene	0.60
MICROGLIA	mediates	cell_type	0.60
STROKE	mediates	disease	0.60
STROKE	protects_against	disease	0.60
NEURON	activates	cell_type	0.60
STROKE	contributes_to	disease	0.60
STROKE	associated_with	disease	0.60
STING	inhibits	gene	0.60
NEURON	causes	cell_type	0.60
LRP1	inhibits	gene	0.60
NEURON	exacerbates	cell_type	0.60
NEURONS	exacerbates	cell_type	0.60
LRP1	protects_against	gene	0.60
NEURON	mediates	cell_type	0.60
MICROGLIA	exacerbates	cell_type	0.60
NEUTROPHIL	exacerbates	cell_type	0.60

Incoming (280)

Source	Relation	Type	Str
ASTROCYTES	activates	cell_type	0.65
IL-6	inhibits	gene	0.65
ISCHEMIA	causes	disease	0.60
AMPK	protects_against	gene	0.60
ATG7	protects_against	gene	0.60
BCL2	protects_against	gene	0.60
ISCHEMIA	interacts_with	disease	0.60
IL6	inhibits	gene	0.60
DEMENTIA	causes	disease	0.60
ASTROCYTE	activates	cell_type	0.60
ALZHEIMER	associated_with	disease	0.60
ALZHEIMER'S	associated_with	disease	0.60
ALZHEIMER'S DISEASE	associated_with	disease	0.60
AKT	activates	gene	0.60
ISCHEMIA	expressed_in	disease	0.60
AMPK	activates	gene	0.60
CANCER	causes	disease	0.60
CANCER	contributes_to	disease	0.60
ISCHEMIA	exacerbates	disease	0.60
ASTROCYTE	mediates	cell_type	0.60
GPX4	treats	gene	0.60
HIPPOCAMPUS	impairs	brain_region	0.60
ACHE	activates	gene	0.60
ASTROCYTE	contributes_to	cell_type	0.60
ASTROCYTES	contributes_to	cell_type	0.60
ASTROCYTE	promotes	cell_type	0.60
DEPRESSION	promotes	disease	0.60
GFAP	promotes	gene	0.60
ENDOTHELIAL	transports	cell_type	0.60
BDNF	mediates	gene	0.60
STROKE	interacts_with	gene	0.50
atherosclerosis	interacts_with	disease	0.50
STROKE	inhibits	gene	0.50
ALZHEIMER	inhibits	gene	0.50
Alzheimer'S Disease	inhibits	disease	0.50
Hypertension	inhibits	disease	0.50
disease	inhibits	disease	0.50
ALZHEIMER'S	inhibits	concept	0.50
Autophagy	associated_with	process	0.50
NEURONS	associated_with	concept	0.50
STROKE	activates	gene	0.50
STROKE	associated_with	gene	0.50
MMP9	activates	gene	0.50
MMP2	activates	gene	0.50
microglia	activates	cell_type	0.50
ANXA1	associated_with	protein	0.50
microglia	associated_with	cell_type	0.50
ANXA1	protects_against	protein	0.50
microglia	protects_against	cell_type	0.50
BRAIN INJURY	protects_against	concept	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ISCHEMIC

Understanding Entity Pages

Summary

Wiki Pages (20)

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

GRIA3 Gene

amyloid-beta-metalloproteinases

DIAN-TU-001 Trial (NCT01760005)

Vascular Cognitive Impairment (VCI)

VEGF/Angiogenesis Pathway in Neurodegeneration

Blood-Brain Barrier Biology and Crossing Strategies

Spinal Cord Stimulation-Affected Neurons

Traumatic Brain Injury and Neurodegeneration Pathway

Excitotoxicity in Neurodegeneration

Astrocytes

creatine-supplementation-neurodegeneration

APP Flemish Mutation (APP Flemish)

FOXO1 Protein

NF-kB Signaling Pathway in Neurodegeneration

Cerebral Small Vessel Disease

Neurogenesis

Pannexin 1 and P2X7 Receptor Signaling in Neurodegeneration