Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| PINK1 | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| SIRT3 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| benchmark_ot_ad_answer_key:PDH | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PAL | upregulates | compound | 0.80 |
| DNM1L | activates | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| KEAP1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MFN1 | activates | gene | 0.60 |
| OPA1 | activates | gene | 0.60 |
| HK2 | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| HIF | activates | gene | 0.60 |
| LDHA | activates | gene | 0.60 |
| MCT1 | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:PDH | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||