Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PV: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Inhibitory Neurons | expressed_in | cell_type | 0.95 |
| motor recovery | promotes | phenotype | 0.95 |
| SST | expressed_in | gene | 0.70 |
| SST | regulates | gene | 0.70 |
| SST | inhibits | gene | 0.70 |
| autism spectrum disorder | expressed_in | disease | 0.70 |
| epilepsy | phosphorylates | disease | 0.60 |
| SST | activates | gene | 0.60 |
| SST | biomarker_for | gene | 0.60 |
| SST | associated_with | gene | 0.60 |
| SST | implicated_in | gene | 0.60 |
| epilepsy | interacts_with | disease | 0.60 |
| epilepsy | associated_with | disease | 0.60 |
| epilepsy | activates | disease | 0.60 |
| schizophrenia | associated_with | disease | 0.60 |
| epilepsy | inhibits | disease | 0.60 |
| epilepsy | implicated_in | disease | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| autism spectrum disorder | implicated_in | disease | 0.60 |
| autism spectrum disorder | inhibits | disease | 0.60 |
| Alzheimer's disease | inhibits | disease | 0.60 |
| Alzheimer's disease | causes | disease | 0.60 |
| Alzheimer's disease | interacts_with | disease | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| benchmark_ot_ad_answer_key:PV | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PNN | activates | gene | 0.80 |
| ACC | regulates | gene | 0.70 |
| HSPA1A | expressed_in | gene | 0.60 |
| GDNF | associated_with | gene | 0.60 |
| CDK5 | activates | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| CDK5 | phosphorylates | gene | 0.60 |
| JAK2 | causes | gene | 0.60 |
| JAK2 | interacts_with | gene | 0.60 |
| JAK2 | associated_with | gene | 0.60 |
| JAK2 | activates | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| NRG1 | inhibits | gene | 0.60 |
| AR | associated_with | gene | 0.60 |
| NMDAR | expressed_in | gene | 0.60 |
| BIN1 | implicated_in | gene | 0.60 |
| BIN1 | causes | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| ALS | co_expressed_with | gene | 0.60 |
| ACC | expressed_in | gene | 0.60 |
| PNN | expressed_in | gene | 0.60 |
| PNN | translocates_to | gene | 0.60 |
| PNN | inhibits | gene | 0.60 |
| GABA | inhibits | gene | 0.60 |
| benchmark_ot_ad_answer_key:PV | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptional and functional profiles of muscarinic receptor-expressing neuron [PMID:41857244] | Tsolias A, Mojica CA, Yamani R, Khanna S | Communications biology | 2026 | 0 |
| Neurophysiological and neuropharmacological effects of melatonin MT2 receptors a [PMID:41571206] | ["Barzon B", "Marchiotto F", "Nasini S", | Biochemical pharmacology | 2026 | 0 |
| Enhanced interhemispheric functional connectivity in elderly anxiety patients wi [PMID:41656398] | ["Chang Y", "Liu M", "Liu Y", "Xie X", " | Scientific reports | 2026 | 0 |
| Convergent transcriptomic and connectomic controllers of information integration [PMID:41606107] | Luppi AI, Uhrig L, Tasserie J, Mediano P | Nature human behaviour | 2026 | 0 |
| Transcranial direct current stimulation restores addictive behavior via prefront [PMID:41136747] | ["Zuo H", "Zhang W", "Wang L", "Wu Y", " | Molecular psychiatry | 2026 | 0 |
| Meta-Analyses of Auditory Evoked Potentials as Alzheimer Biomarkers. [PMID:40836165] | Bayat A, Mirmomeni G, Aiken S, Jafari Z | Ear and hearing | 2026 | 0 |
| Establishing mouse forebrain organoids as models of intrinsic cortical network a [PMID:41791384] | Hernandez S, Schweiger HE, Cline I, Kaur | Stem cell reports | 2026 | 0 |
| Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138] | Singer Y, Yitzhaky A, Hertzberg L | Alpha psychiatry | 2026 | 0 |
| A silent Kv channel subunit shapes PV neuron action potential waveform and short [PMID:41632839] | Ganesh S, Canty TM, Sabatini BL | Proceedings of the National Ac | 2026 | 0 |
| Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068] | Yang S, Wang X, Yan Y, Zhang J, Wei Y et | J Affect Disord | 2026 | 0 |
| External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987] | Vadalà A, Benelli C, Suraci F, Carta B, | Arch Orthop Trauma Surg | 2026 | 0 |
| Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomati [PMID:41279752] | Mandal P, Trushina E, Arnold M, Kaddurah | bioRxiv : the preprint server | 2025 | 0 |
| Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Pre [PMID:40426616] | ["Liu W", "Li N", "Tang D", "Qin L", "Zh | Brain sciences | 2025 | 0 |
| Medial prefrontal cortex circuit dynamics involved in stage-specific addiction. [PMID:41307570] | ["Zhao D", "Zhang X", "Bai J"] | Brain structure & function | 2025 | 0 |
| Studies in rats of a target specific and reversible general anesthetic with a fa [PMID:41187127] | ["Xie Z", "Fong R", "Fox A"] | PloS one | 2025 | 0 |
| tDCS-induced enhancement of cognitive flexibility in autism: role of frontal lob [PMID:40874060] | ["Han Y", "Dong A", "Xia C", "Zhang Z", | Frontiers in behavioral neuros | 2025 | 0 |
| Fate plasticity of interneuron specification. [PMID:40264797] | ["Mostajo-Radji M", "Leon W", "Breevoort | iScience | 2025 | 0 |
| Fate plasticity of interneuron specification. [PMID:40264797] | Mostajo-Radji MA, Leon WRM, Breevoort A, | iScience | 2025 | 0 |
| Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475] | Bershteyn M, Zhou H, Fuentealba L, Chen | Neuron | 2025 | 0 |
| Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284] | Walsh RM, Crabtree GW, Kalpana K, Jubier | Neuron | 2025 | 0 |