gene

RAB39B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB39B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections
0Hypotheses
0Analyses
14Outgoing
12Incoming

Summary

RAB39B is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, implicated in. Associated with Als, Autism, Ms. Connected to 13 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolRAB39B
Full NameRAB39B, Member RAS Oncogene Family
FunctionMultiple
Primary Expressionthe brain, with highest levels in the substantia nigra, hippocampus, and cerebral cortex
Molecular Weight26 kDa
Amino Acids235 aa
Exons8
GeneCardsRAB39B
Human Protein AtlasRAB39B
RegionExpression Level
Substantia nigraHigh
CortexMedium-High
HippocampusMedium
CerebellumMedium
FeatureRAB39B
Associated DiseasesAls, Autism, Ms, Parkinson, Parkinson's disease
InteractionsPI3K, C9ORF72
KG Connections26 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RAB39B Gene

gene · 2455 words

Synaptic Vesicle Trafficking in Parkinson's Disease

mechanism · 4417 words

Gene-Mechanism-Therapy Causal Chains

mechanism · 4075 words

Endosomal Trafficking Pathway

mechanism · 3217 words

autophagy-lysosome-dysfunction

mechanism · 3147 words

RAB35 — Ras-Associated Protein 35

gene · 2932 words

Pathway Diagram

graph TD
    RAB39B["<b>RAB39B</b>"]
    Parkinson{"Parkinson"}
    RAB39B -->|"associated with"| Parkinson
    Als{"Als"}
    RAB39B -->|"associated with"| Als
    Ms{"Ms"}
    RAB39B -->|"associated with"| Ms
    Autism{"Autism"}
    RAB39B -->|"associated with"| Autism
    PI3K["PI3K"]
    RAB39B -->|"interacts with"| PI3K
    AKT["AKT"]
    RAB39B -->|"associated with"| AKT
    AUTOPHAGY["AUTOPHAGY"]
    RAB39B -->|"associated with"| AUTOPHAGY
    C9ORF72["C9ORF72"]
    RAB39B -->|"interacts with"| C9ORF72
    Autophagy(["Autophagy"])
    RAB39B -->|"associated with"| Autophagy
    Akt(["Akt"])
    RAB39B -->|"associated with"| Akt
    Pi3K(["Pi3K"])
    RAB39B -->|"interacts with"| Pi3K
    neurodegeneration["neurodegeneration"]
    RAB39B -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| RAB39B
    style RAB39B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

TargetRelationTypeStr
Parkinsonassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
Autismassociated_withdisease0.65
PI3Kinteracts_withgene0.60

Incoming (12)

SourceRelationTypeStr
PI3Kinteracts_withgene0.60
ATP13A2associated_withgene0.60
ATXN2associated_withgene0.60
DNAJC13associated_withgene0.60
FBXO7associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found