Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB39B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB39B is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, implicated in. Associated with Als, Autism, Ms. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | RAB39B |
| Full Name | RAB39B, Member RAS Oncogene Family |
| Function | Multiple |
| Primary Expression | the brain, with highest levels in the substantia nigra, hippocampus, and cerebral cortex |
| Molecular Weight | 26 kDa |
| Amino Acids | 235 aa |
| Exons | 8 |
| GeneCards | RAB39B |
| Human Protein Atlas | RAB39B |
| Region | Expression Level |
| Substantia nigra | High |
| Cortex | Medium-High |
| Hippocampus | Medium |
| Cerebellum | Medium |
| Feature | RAB39B |
| Associated Diseases | Als, Autism, Ms, Parkinson, Parkinson's disease |
| Interactions | PI3K, C9ORF72 |
| KG Connections | 26 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB39B["<b>RAB39B</b>"]
Parkinson{"Parkinson"}
RAB39B -->|"associated with"| Parkinson
Als{"Als"}
RAB39B -->|"associated with"| Als
Ms{"Ms"}
RAB39B -->|"associated with"| Ms
Autism{"Autism"}
RAB39B -->|"associated with"| Autism
PI3K["PI3K"]
RAB39B -->|"interacts with"| PI3K
AKT["AKT"]
RAB39B -->|"associated with"| AKT
AUTOPHAGY["AUTOPHAGY"]
RAB39B -->|"associated with"| AUTOPHAGY
C9ORF72["C9ORF72"]
RAB39B -->|"interacts with"| C9ORF72
Autophagy(["Autophagy"])
RAB39B -->|"associated with"| Autophagy
Akt(["Akt"])
RAB39B -->|"associated with"| Akt
Pi3K(["Pi3K"])
RAB39B -->|"interacts with"| Pi3K
neurodegeneration["neurodegeneration"]
RAB39B -->|"implicated in"| neurodegeneration
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| RAB39B
style RAB39B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| PI3K | interacts_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| C9ORF72 | interacts_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Akt | associated_with | pathway | 0.60 |
| Pi3K | interacts_with | pathway | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| Parkinson's disease | associated_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K | interacts_with | gene | 0.60 |
| ATP13A2 | associated_with | gene | 0.60 |
| ATXN2 | associated_with | gene | 0.60 |
| DNAJC13 | associated_with | gene | 0.60 |
| FBXO7 | associated_with | gene | 0.60 |
| GBA | associated_with | gene | 0.60 |
| GCH1 | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| PLA2G6 | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||