RAB7L1

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB7L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

RAB7L1 is a Rab GTPase involved in late endosomal/lysosomal trafficking, implicated in Parkinson's disease risk through GWAS and LRRK2 interaction.

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graph TD
    RAB7L1["<b>RAB7L1</b>"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    RAB7L1 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    RAB7L1 -->|"activates"| Ms
    Dementia{"Dementia"}
    RAB7L1 -->|"regulates"| Dementia
    Als{"Als"}
    RAB7L1 -->|"activates"| Als
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    RAB7L1 -->|"regulates"| Frontotemporal_Dementia
    Ftd{"Ftd"}
    RAB7L1 -->|"activates"| Ftd
    Neuroblastoma{"Neuroblastoma"}
    RAB7L1 -->|"interacts with"| Neuroblastoma
    Parkinson{"Parkinson"}
    RAB7L1 -->|"interacts with"| Parkinson
    RAB7L1 -->|"interacts with"| Ms
    RAB7L1 -->|"inhibits"| Ms
    ALS{"ALS"}
    RAB7L1 -->|"activates"| ALS
    GAIN["GAIN"]
    RAB7L1 -->|"activates"| GAIN
    GAIN -->|"activates"| RAB7L1
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"regulates"| RAB7L1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| RAB7L1
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"transports"| RAB7L1
    GAIN -->|"transports"| RAB7L1
    VESICLE_TRAFFICKING["VESICLE TRAFFICKING"]
    VESICLE_TRAFFICKING -->|"regulates"| RAB7L1
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"regulates"| RAB7L1
    AND["AND"]
    AND -->|"activates"| RAB7L1
    style RAB7L1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0