PIN1

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for PIN1 — Peptidyl-prolyl cis-trans Isomerase NIMA-Interacting 1

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graph TD
    PIN1["<b>PIN1</b>"]
    TRIM32["TRIM32"]
    PIN1 -->|"phosphorylates"| TRIM32
    SUMO2_3["SUMO2/3"]
    PIN1 -->|"binds"| SUMO2_3
    SENP1["SENP1"]
    PIN1 -->|"binds"| SENP1
    NRF2["NRF2"]
    PIN1 -->|"binds"| NRF2
    ANXA2["ANXA2"]
    PIN1 -->|"phosphorylates"| ANXA2
    Alzheimer_s_disease{"Alzheimer's disease"}
    PIN1 -->|"associated with"| Alzheimer_s_disease
    Aging{"Aging"}
    PIN1 -->|"regulates"| Aging
    Neurodegeneration{"Neurodegeneration"}
    PIN1 -->|"regulates"| Neurodegeneration
    Als{"Als"}
    PIN1 -->|"regulates"| Als
    Cancer{"Cancer"}
    PIN1 -->|"regulates"| Cancer
    Longevity{"Longevity"}
    PIN1 -->|"regulates"| Longevity
    Ms{"Ms"}
    PIN1 -->|"regulates"| Ms
    PKM2["PKM2"]
    PKM2 -->|"binds"| PIN1
    AGING["AGING"]
    AGING -->|"regulates"| PIN1
    SIRT6["SIRT6"]
    SIRT6 -->|"regulates"| PIN1
    PARP1["PARP1"]
    PARP1 -->|"regulates"| PIN1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| PIN1
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"regulates"| PIN1
    P53["P53"]
    P53 -->|"regulates"| PIN1
    MYC["MYC"]
    MYC -->|"regulates"| PIN1
    DDX5["DDX5"]
    DDX5 -->|"regulates"| PIN1
    style PIN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0