gene

SLC17A5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC17A5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

0Hypotheses

0Analyses

45Outgoing

25Incoming

Summary

SLC17A5 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in, contributes to. Associated with Aging, Als, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SLC17A5
Full Name	Solute Carrier Family 17 Member 5 (Sialin)
Chromosome	6q13
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	495 aa
Exons	14
Pathways	Alpha-Synuclein, Cholesterol
UniProt ID	[Q9NRX3](https://www.uniprot.org/uniprot/Q9NRX3)
Ensembl ID	ENSG00000183040
GeneCards	SLC17A5
Human Protein Atlas	SLC17A5
Exon count	14 exons spanning approximately 25 kb
Promoter region	Contains regulatory elements for tissue-specific expression
Coding sequence	Encodes a polytopic membrane protein with 10-12 transmembrane domains
Lysosomal export	Exports sialic acid from lysosomes using the proton gradient as energy source[@sialin2019]
Associated Diseases	ALS, Aging, Ms, Parkinson
Interactions	GNPTAB, SMPD1, NPC1, GBA, CTSD, LIPA
KG Connections	70 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC17A5["<b>SLC17A5</b>"]
    Parkinson_s_disease{"Parkinson's disease"}
    SLC17A5 -->|"contributes to"| Parkinson_s_disease
    Parkinson{"Parkinson"}
    SLC17A5 -->|"associated with"| Parkinson
    Als{"Als"}
    SLC17A5 -->|"associated with"| Als
    Aging{"Aging"}
    SLC17A5 -->|"associated with"| Aging
    Ms{"Ms"}
    SLC17A5 -->|"associated with"| Ms
    GBA["GBA"]
    SLC17A5 -->|"associated with"| GBA
    neurodegeneration["neurodegeneration"]
    SLC17A5 -->|"implicated in"| neurodegeneration
    GENES["GENES"]
    GENES -->|"associated with"| SLC17A5
    SMPD1["SMPD1"]
    SMPD1 -->|"associated with"| SLC17A5
    CTSD["CTSD"]
    CTSD -->|"associated with"| SLC17A5
    style SLC17A5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
Alpha-Synuclein Neurotoxicity	modulates	phenotype	0.85
Parkinson's disease	contributes_to	disease	0.80
Retinal Degeneration	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Parkinson	activates	disease	0.65
ALS	associated_with	disease	0.65
Lewy Body	activates	disease	0.65
ALS	activates	disease	0.65
GBA	associated_with	gene	0.60
ASAH1	associated_with	gene	0.60
SMPD1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
GNPTAB	activates	gene	0.60
SMPD1	activates	gene	0.60
NPC1	activates	gene	0.60
GBA	activates	gene	0.60
CTSD	activates	gene	0.60
LIPA	activates	gene	0.60
SCARB2	activates	gene	0.60
Rb	activates	protein	0.60
SMPD1	interacts_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
LYSOSOMAL STORAGE DISORDER GENE VARIANTS	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
AGING	activates	gene	0.60
Cholesterol	activates	pathway	0.60
AND	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
Alpha-Synuclein	activates	pathway	0.60
Α-Synuclein	activates	protein	0.60
Parkinson's disease	interacts_with	disease	0.60
SMPD1	co_expressed_with	gene	0.50
PARKINSON	interacts_with	gene	0.50
Parkinson's Disease	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
PARKINSON'S	interacts_with	concept	0.50

Incoming (25)

Source	Relation	Type	Str
SMPD1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
SCARB2	activates	gene	0.60
LIPA	activates	gene	0.60
ASAH1	associated_with	gene	0.60
SMPD1	activates	gene	0.60
GBA	associated_with	gene	0.60
GNPTAB	activates	gene	0.60
NPC1	activates	gene	0.60
GBA	activates	gene	0.60
ASAH1	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
PARKINSON	activates	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
GENES	activates	gene	0.60
SMPD1	interacts_with	gene	0.50
CTSD	interacts_with	gene	0.50
CTSD	activates	gene	0.50
CTSD	co_expressed_with	gene	0.50
GBA	co_expressed_with	gene	0.50
asah1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC17A5

Understanding Entity Pages

Summary

Wiki Pages (9)

SLC17A5 Gene

VGLUT2 Gene

Lysosomal Autophagy Neuron

GNPTAB — N-Acetylglucosamine-1-Phosphate Transferase Alpha/Beta

ASAH1 — N-Acylsphingosine Amidohydrolase 1

Nucleus Tractus Solitarius Neurons

SLC17A5 Protein