Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about asah1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ASAH1 |
| Full Name | N-Acylsphingosine Amidohydrolase 1 (Acid Ceramidase) |
| Chromosome | 8p22 |
| Protein Type | Enzyme |
| Function | is a lysosomal enzyme that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids. |
| Molecular Weight | ~44 kDa (precursor), ~13+20 kDa (processed) |
| Amino Acids | 395 aa |
| Exons | 16 |
| Pathways | Sphingolipid |
| UniProt ID | [Q13510](https://www.uniprot.org/uniprot/Q13510) |
| Ensembl ID | ENSG00000104522 |
| OMIM | 613468 |
| GeneCards | ASAH1 |
| Human Protein Atlas | ASAH1 |
| Associated Diseases | ALS through: |
| Interactions | SMPD1, CTSD, SLC17A5, PARKINSON |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ASAH1["ASAH1"]
ASAH1 -->|"involved_in"| Sphingolipid_Metabolism["Sphingolipid Metabolism"]
ASAH1 -->|"contributes to"| Parkinson_s_disease["Parkinson's disease"]
ASAH1 -->|"activates"| Alzheimer["Alzheimer"]
ASAH1 -->|"activates"| Als["Als"]
ASAH1 -->|"expressed in"| Ischemia["Ischemia"]
ASAH1 -->|"expressed in"| Stroke["Stroke"]
ASAH1 -->|"activates"| ALS["ALS"]
SGMS2["SGMS2"] -->|"activates"| ASAH1
AMYLOID["AMYLOID"] -->|"activates"| ASAH1
CERS6["CERS6"] -->|"activates"| ASAH1
ALZHEIMER["ALZHEIMER"] -->|"activates"| ASAH1
STROKE["STROKE"] -->|"expressed in"| ASAH1
APOPTOSIS["APOPTOSIS"] -->|"expressed in"| ASAH1
GENES["GENES"] -->|"activates"| ASAH1| Target | Relation | Type | Str |
|---|---|---|---|
| CERAMIDE | activates | concept | 0.50 |
| Sphingolipid | regulates | pathway | 0.50 |
| SGMS1 | regulates | concept | 0.50 |
| SMPD1 | interacts_with | gene | 0.50 |
| CTSD | interacts_with | gene | 0.50 |
| SLC17A5 | interacts_with | gene | 0.50 |
| PARKINSON | interacts_with | gene | 0.50 |
| Parkinson's Disease | interacts_with | disease | 0.50 |
| disease | interacts_with | disease | 0.50 |
| PARKINSON'S | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC17A5 | associated_with | gene | 0.60 |
| SGMS2 | activates | gene | 0.60 |
| CERS6 | activates | gene | 0.60 |
| SGMS2 | contributes_to | gene | 0.60 |
| SMPD1 | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| STROKE | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| SGMS2 | associated_with | gene | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||