gene

LIPA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIPA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

169Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

LIPA Gene

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🧬 Gene Info

Gene Symbol	LIPA
Protein Type	Enzyme
Function	LIPA encodes lysosomal acid lipase (LIPA or LAL), a crucial enzyme that hydrolyzes cholesteryl esters and triglycerides in the lysosome.
Primary Expression	neurons, astrocytes, and microglia, with particular importance in lipid-rich region
Pathways	Cholesterol, Alpha-Synuclein, Lipid Metabolism, Phagocytosis, Apoptosis
Ensembl ID	ENSG00000107796
GeneCards	LIPA
Human Protein Atlas	LIPA
Cholesteryl ester hydrolysis	Converting cholesteryl esters to free cholesterol and fatty acids
Triglyceride catabolism	Breaking down triglycerides for energy utilization
Lipoprotein processing	Essential for chylomicron and LDL metabolism
Autophagic flux	Involved in lipid droplet degradation via autophagy
Associated Diseases	ALS, Alzheimer
Interactions	SLC17A5, GNPTAB, SMPD1, NPC1, GBA, CTSD
KG Connections	169 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LIPA["LIPA"]
    Neurodegeneration["Neurodegeneration"]
    Als["Als"]
    Aging["Aging"]
    Parkinson["Parkinson"]
    Alzheimer["Alzheimer"]
    Atherosclerosis["Atherosclerosis"]
    SLC17A5["SLC17A5"]
    GNPTAB["GNPTAB"]
    SMPD1["SMPD1"]
    NPC1["NPC1"]
    GBA["GBA"]
    CTSD["CTSD"]
    AGING["AGING"]
    Cholesterol["Cholesterol"]
    ALZHEIMER["ALZHEIMER"]
    APP["APP"]
    APOE["APOE"]
    CYP46A1["CYP46A1"]
    ABCA1["ABCA1"]
    LIPA -->|"activates"| Neurodegeneration
    LIPA -->|"activates"| Als
    LIPA -->|"activates"| Aging
    LIPA -->|"activates"| Parkinson
    LIPA -->|"regulates"| Alzheimer
    LIPA -->|"regulates"| Als
    LIPA -->|"regulates"| Atherosclerosis
    LIPA -->|"activates"| SLC17A5
    LIPA -->|"activates"| GNPTAB
    LIPA -->|"activates"| SMPD1
    LIPA -->|"activates"| NPC1
    LIPA -->|"activates"| GBA
    LIPA -->|"activates"| CTSD
    LIPA -->|"activates"| AGING
    LIPA -->|"activates"| Cholesterol
    LIPA -->|"regulates"| ALZHEIMER
    LIPA -->|"regulates"| APP
    LIPA -->|"regulates"| APOE
    LIPA -->|"regulates"| CYP46A1
    LIPA -->|"regulates"| ABCA1
    style LIPA fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (109)

Target	Relation	Type	Str
Alpha-Synuclein-Induced Retinal Degeneration	modulates	phenotype	0.85
Retinal Degeneration	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Lewy Body	activates	disease	0.65
ALS	activates	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
ALS	transports	disease	0.65
Atherosclerosis	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Als	degrades	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Stroke	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
SLC17A5	activates	gene	0.60
GNPTAB	activates	gene	0.60
SMPD1	activates	gene	0.60
NPC1	activates	gene	0.60
GBA	activates	gene	0.60
CTSD	activates	gene	0.60
APP	regulates	gene	0.60
APOE	regulates	gene	0.60
CYP46A1	regulates	gene	0.60
ABCA1	regulates	gene	0.60
NCSTN	regulates	gene	0.60
GSK3B	regulates	gene	0.60
PSEN1	regulates	gene	0.60
SREBF1	regulates	gene	0.60
APOC1	regulates	gene	0.60
APOC2	regulates	gene	0.60
SOAT1	regulates	gene	0.60
ABCA2	regulates	gene	0.60
PSEN2	regulates	gene	0.60
TAU	regulates	gene	0.60
LDLR	regulates	gene	0.60
APOC3	regulates	gene	0.60
SCARB2	activates	gene	0.60
LDLR	transports	gene	0.60
ABCA1	transports	gene	0.60
GSK3B	transports	gene	0.60
LRP8	transports	gene	0.60
APOA1	transports	gene	0.60
CYP46A1	transports	gene	0.60
SOAT1	transports	gene	0.60

Incoming (60)

Source	Relation	Type	Str
SCARB2	activates	gene	0.60
LRP8	regulates	gene	0.60
APOA1	regulates	gene	0.60
MAPT	regulates	gene	0.60
LRP1	regulates	gene	0.60
SMPD1	activates	gene	0.60
SLC17A5	activates	gene	0.60
NPC1	activates	gene	0.60
APOE	transports	gene	0.60
NCSTN	transports	gene	0.60
PSEN2	transports	gene	0.60
GNPTAB	activates	gene	0.60
GBA	activates	gene	0.60
APOE	activates	gene	0.60
PLIN2	activates	gene	0.60
SOAT1	activates	gene	0.60
ABCA1	activates	gene	0.60
CTSD	activates	gene	0.60
LRP1	degrades	gene	0.60
APOC3	degrades	gene	0.60
CYP46A1	degrades	gene	0.60
APP	degrades	gene	0.60
PSEN2	degrades	gene	0.60
APOA1	degrades	gene	0.60
LRP8	degrades	gene	0.60
MAPT	degrades	gene	0.60
SREBF1	degrades	gene	0.60
NCSTN	degrades	gene	0.60
PSEN1	degrades	gene	0.60
LDLR	degrades	gene	0.60
APOE	degrades	gene	0.60
ABCA1	degrades	gene	0.60
APOC1	degrades	gene	0.60
SOAT1	degrades	gene	0.60
ABCA2	degrades	gene	0.60
GSK3B	degrades	gene	0.60
APOC2	degrades	gene	0.60
TAU	degrades	gene	0.60
LC3	activates	gene	0.60
CADM1	biomarker_for	gene	0.60
PARKINSON	activates	gene	0.60
CH25H	regulates	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
GENES	activates	gene	0.60
STROKE	expressed_in	gene	0.60
MICROGLIA	activates	gene	0.60
CH25H	degrades	gene	0.60
ALZHEIMER	degrades	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

neurodegeneration | 2026-04-15 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LIPA

Understanding Entity Pages

Summary

Wiki Pages (14)

LIPA Gene

Section 189: Advanced Autophagy-Endolysosomal Pathway Therapy in CBS/PSP

Section 244: Advanced Autophagy Induction and TFEB Activation in CBS/PSP

GPNMB Modulation for Lipid-Laden Microglia Rescue

Lipophagy Activation Therapy for Neurodegeneration

TFEB-Mediated Lysosomal Biogenesis

Lysosomal Acid Lipase (LIPA) Modulators

GNPTAB — N-Acetylglucosamine-1-Phosphate Transferase Alpha/Beta

PSP Lysosomal Dysfunction and Autophagy Impairment

Lipophagy Pathway in Neurodegeneration

TFE3 Gene

Lysosomal Acid Lipase (LIPA) Protein

Proteins