protein

Lewy Body

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Lewy Body: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

257Connections

0Hypotheses

0Analyses

35Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	LEWY BODY
Associated Diseases	PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE
KG Connections	85 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Lewy_Body["Lewy Body"] -->|"causes"| Protein_Aggregation["Protein Aggregation"]
    style Protein_Aggregation fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Lewy_Body["Lewy Body"] -->|"causes"| Alpha_Synuclein["Alpha-Synuclein"]
    style Alpha_Synuclein fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Lewy_Body["Lewy Body"] -->|"associated"| Epigenetic["Epigenetic"]
    style Epigenetic fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Lewy_Body["Lewy Body"] -->|"associated"| Autophagy["Autophagy"]
    style Autophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Lewy_Body["Lewy Body"] -->|"activates"| Microglia_Activation["Microglia Activation"]
    style Microglia_Activation fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Lewy_Body["Lewy Body"] -->|"associated"| Oxidative_Stress["Oxidative Stress"]
    style Oxidative_Stress fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Lewy_Body["Lewy Body"] -->|"contributes to"| Amyloid["Amyloid"]
    style Amyloid fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    SNCA["SNCA"] -->|"involved in"| Lewy_Body["Lewy Body"]
    style SNCA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    DEMENTIA["DEMENTIA"] -->|"contributes to"| Lewy_Body["Lewy Body"]
    style DEMENTIA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CD4["CD4"] -->|"regulates"| Lewy_Body["Lewy Body"]
    style CD4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"causes"| Lewy_Body["Lewy Body"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PARKINSON["PARKINSON"] -->|"causes"| Lewy_Body["Lewy Body"]
    style PARKINSON fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Lewy_Body fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (60)

Target	Relation	Type	Str
Protein Aggregation	causes	pathway	0.55
Alpha-Synuclein	causes	pathway	0.55
Epigenetic	associated_with	pathway	0.55
Autophagy	associated_with	pathway	0.55
Microglia Activation	activates	pathway	0.55
Alpha-Synuclein	activates	pathway	0.55
Alpha-Synuclein	expressed_in	pathway	0.55
Oxidative Stress	associated_with	pathway	0.55
Amyloid	contributes_to	pathway	0.55
Amyloid	activates	pathway	0.55
Lipid Metabolism	expressed_in	pathway	0.55
T Cell	regulates	cell_type	0.55
Neuron	regulates	cell_type	0.55
Dopaminergic	regulates	cell_type	0.55
Neuron	causes	cell_type	0.55
T Cell	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Neuron	therapeutic_target	cell_type	0.55
Dopaminergic	therapeutic_target	cell_type	0.55
Microglia	activates	cell_type	0.55
Macrophage	activates	cell_type	0.55
Cholesterol	activates	pathway	0.55
Microglia	associated_with	cell_type	0.55
Oxidative Stress	therapeutic_target	pathway	0.55
Mitochondrial Function	causes	pathway	0.55
Microglia	causes	cell_type	0.55
Neuron	stabilizes	cell_type	0.55
Dopaminergic	expressed_in	cell_type	0.55
Prefrontal Cortex	associated_with	brain_region	0.50
Cortex	associated_with	brain_region	0.50
Thalamus	associated_with	brain_region	0.50
Locus Coeruleus	associated_with	brain_region	0.50
Hypothalamus	associated_with	brain_region	0.50
Temporal Lobe	associated_with	brain_region	0.50

Incoming (197)

Source	Relation	Type	Str
DEMENTIA	contributes_to	gene	0.65
CD4	regulates	gene	0.65
PARKINSON'S DISEASE	causes	gene	0.65
PARKINSON	causes	gene	0.65
NEURODEGENERATIVE DISORDERS	causes	gene	0.65
GUT-BRAIN AXIS	causes	gene	0.65
INFLAMMATION	causes	gene	0.65
NEURODEGENERATION	causes	gene	0.65
ALPHA-SYNUCLEIN	causes	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.65
AGING	causes	gene	0.65
PARKINSON	associated_with	gene	0.65
DEMENTIA	associated_with	gene	0.65
ALZHEIMER	associated_with	gene	0.65
AND	associated_with	gene	0.65
NEURODEGENERATIVE DISEASES	associated_with	gene	0.65
ALZHEIMER'S DISEASE	associated_with	gene	0.65
PARKINSON'S DISEASE	associated_with	gene	0.65
GAIN	causes	gene	0.65
ATG7	associated_with	gene	0.65
NEURON	associated_with	gene	0.65
NEURODEGENERATION	associated_with	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
AGING	expressed_in	gene	0.65
ATG7	expressed_in	gene	0.65
P62	expressed_in	gene	0.65
NEURON	expressed_in	gene	0.65
NEURODEGENERATION	expressed_in	gene	0.65
ALPHA-SYNUCLEIN	associated_with	gene	0.65
AND	regulates	gene	0.65
NEURODEGENERATION	therapeutic_target	gene	0.65
OVERVIEW	therapeutic_target	gene	0.65
AND	causes	gene	0.65
RNA	regulates	gene	0.65
GENES	expressed_in	gene	0.65
NEUROINFLAMMATION	expressed_in	gene	0.65
ASTROCYTE	expressed_in	gene	0.65
PARKINSON	expressed_in	gene	0.65
ALZHEIMER	expressed_in	gene	0.65
AND	expressed_in	gene	0.65
ALZHEIMER'S DISEASE	expressed_in	gene	0.65
PARKINSON'S DISEASE	expressed_in	gene	0.65
PARKINSON'S DISEASE	contributes_to	gene	0.65
AND	contributes_to	gene	0.65
PARKINSON	contributes_to	gene	0.65
AND	biomarker_for	gene	0.65
EPILEPSY	regulates	gene	0.65
MICROGLIA ACTIVATION	activates	gene	0.65
NEUROINFLAMMATION	activates	gene	0.65
ALZHEIMER	regulates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Lewy Body

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

Therapeutics

Frontotemporal Dementia (FTD) Mechanistic Pathway

Multiple System Atrophy

Alzheimer's Disease

Frontotemporal Dementia (FTD)

nct07165106

NTF4 Protein

GSK-3β in Neurodegeneration

p-tau-217