concept

SOD1 MUTATIONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD1 MUTATIONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

1Analyses

48Outgoing

33Incoming

0Experiments

1Debates

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💡 Concept Info

Name	SOD1 MUTATIONS
Key Genes/Proteins	AMYLOID, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND, ATXN2, C9ORF72
Related Diseases	Als, ALS, Amyotrophic Lateral Sclerosis, Dementia, disease
Related Pathways	Ferroptosis

Pathway Diagram

graph TD
    SOD1_MUTATIONS["SOD1 MUTATIONS"]
    SOD1_MUTATIONS -->|"causes"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    SOD1_MUTATIONS -->|"inhibits"| SOD1_enzyme_activity["SOD1 enzyme activity"]
    SOD1_MUTATIONS -->|"target for"| Als["Als"]
    SOD1_MUTATIONS -->|"inhibits"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SOD1_MUTATIONS -->|"inhibits"| Dementia["Dementia"]
    SOD1_MUTATIONS -->|"inhibits"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    SOD1["SOD1"] -->|"target for"| SOD1_MUTATIONS
    ATXN2["ATXN2"] -->|"target for"| SOD1_MUTATIONS
    JUN["JUN"] -->|"inhibits"| SOD1_MUTATIONS
    NEURON["NEURON"] -->|"inhibits"| SOD1_MUTATIONS
    TARDBP["TARDBP"] -->|"inhibits"| SOD1_MUTATIONS
    DEMENTIA["DEMENTIA"] -->|"inhibits"| SOD1_MUTATIONS
    C9ORF72["C9ORF72"] -->|"treats"| SOD1_MUTATIONS
    HEXANUCLEOTIDE_REPEAT_EXPANSIO["HEXANUCLEOTIDE REPEAT EXPANSIONS"] -->|"treats"| SOD1_MUTATIONS
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"target for"| SOD1_MUTATIONS
    FUS["FUS"] -->|"treats"| SOD1_MUTATIONS

Outgoing (48)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SOD1 MUTATIONS	data_in	dataset_row	0.00
amyotrophic lateral sclerosis	causes	disease	0.95
SOD1 enzyme activity	inhibits	phenotype	0.90
Amyotrophic Lateral Sclerosis	causes	disease	0.90
ALS	risk_factor_for	disease	0.90
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.90
Als	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Als	treats	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Frontotemporal Dementia	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	therapeutic_target	gene	0.60
HEXANUCLEOTIDE REPEAT EXPANSIONS	therapeutic_target	gene	0.60
TARDBP	inhibits	gene	0.60
SOD1	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
FUS	therapeutic_target	gene	0.60
SOD1	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
Oxidative Stress	activates	pathway	0.60
SOD1	treats	gene	0.60
Sod1	associated_with	pathway	0.60
ATXN2	treats	gene	0.60
NEURON	associated_with	gene	0.60
SOD1	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
GAIN	therapeutic_target	gene	0.60
GENE MUTATIONS	therapeutic_target	gene	0.60
ALS	expressed_in	gene	0.60
NEURON	inhibits	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
Tdp-43	inhibits	pathway	0.60
SOD1	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
MOTOR NEURONS	associated_with	gene	0.60
Spinal Cord	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (33)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SOD1 MUTATIONS	data_in	dataset_row	0.00
20953194	confer toxic functions that impair	paper	0.90
JUN	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
ALS	associated_with	gene	0.60
TARDBP	inhibits	gene	0.60
C9ORF72	treats	gene	0.60
SOD1	therapeutic_target	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
MOTOR NEURONS	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
HEXANUCLEOTIDE REPEAT EXPANSIONS	treats	gene	0.60
ATXN2	therapeutic_target	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
FUS	treats	gene	0.60
ALS	treats	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
TDP-43	inhibits	gene	0.60
RNA	inhibits	gene	0.60
SOD1	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
GAIN	associated_with	gene	0.60
ALS	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
AMYLOID	activates	gene	0.60
AND	activates	gene	0.60
Sod1	associated_with	gene	0.50
amyotrophic lateral sclerosis	associated_with	gene	0.50
disease	associated_with	disease	0.50
Sod1	interacts_with	gene	0.50
amyotrophic lateral sclerosis	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons

neurodegeneration | 2026-04-27 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream

closed · Rounds: 6 · Score: 0.62 · 2026-04-27

Related Research

Hypotheses and analyses mentioning SOD1 MUTATIONS in their description or question text

No additional research found