concept

SOD1 MUTATIONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD1 MUTATIONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

0Analyses

46Outgoing

37Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SOD1 MUTATIONS
Key Genes/Proteins	TARDBP, FUS
Related Diseases	Als, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, ALS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SOD1_MUTATIONS["SOD1 MUTATIONS"]
    SOD1_MUTATIONS -->|"causes"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    SOD1_MUTATIONS -->|"inhibits"| SOD1_enzyme_activity["SOD1 enzyme activity"]
    SOD1_MUTATIONS -->|"target for"| Als["Als"]
    SOD1_MUTATIONS -->|"inhibits"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SOD1_MUTATIONS -->|"inhibits"| Dementia["Dementia"]
    SOD1_MUTATIONS -->|"inhibits"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    SOD1["SOD1"] -->|"target for"| SOD1_MUTATIONS
    ATXN2["ATXN2"] -->|"target for"| SOD1_MUTATIONS
    JUN["JUN"] -->|"inhibits"| SOD1_MUTATIONS
    NEURON["NEURON"] -->|"inhibits"| SOD1_MUTATIONS
    TARDBP["TARDBP"] -->|"inhibits"| SOD1_MUTATIONS
    DEMENTIA["DEMENTIA"] -->|"inhibits"| SOD1_MUTATIONS
    C9ORF72["C9ORF72"] -->|"treats"| SOD1_MUTATIONS
    HEXANUCLEOTIDE_REPEAT_EXPANSIO["HEXANUCLEOTIDE REPEAT EXPANSIONS"] -->|"treats"| SOD1_MUTATIONS
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"target for"| SOD1_MUTATIONS
    FUS["FUS"] -->|"treats"| SOD1_MUTATIONS

Outgoing (51)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Frontotemporal Dementia	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Als	treats	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.65
TARDBP	inhibits	gene	0.60
FUS	therapeutic_target	gene	0.60
SOD1	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
HEXANUCLEOTIDE REPEAT EXPANSIONS	therapeutic_target	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
Tdp-43	inhibits	pathway	0.60
Sod1	associated_with	pathway	0.60
SOD1	treats	gene	0.60
ATXN2	treats	gene	0.60
SOD1	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
NEURON	associated_with	gene	0.60
Oxidative Stress	activates	pathway	0.60
ALS	expressed_in	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
GAIN	therapeutic_target	gene	0.60
GENE MUTATIONS	therapeutic_target	gene	0.60
SOD1	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
MOTOR NEURONS	associated_with	gene	0.60
AND	associated_with	gene	0.60
NEURON	inhibits	gene	0.60
Sod1	contributes_to	pathway	0.60
Spinal Cord	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (38)

Source	Relation	Type	Str
SOD1	therapeutic_target	gene	0.60
ATXN2	therapeutic_target	gene	0.60
JUN	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
SOD1	associated_with	gene	0.60
ALS	associated_with	gene	0.60
TARDBP	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
C9ORF72	treats	gene	0.60
HEXANUCLEOTIDE REPEAT EXPANSIONS	treats	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
FUS	treats	gene	0.60
ALS	treats	gene	0.60
ALS	activates	gene	0.60
AND	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
AMYLOID	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
MOTOR NEURONS	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
TDP-43	inhibits	gene	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
AND	associated_with	gene	0.60
SOD1	contributes_to	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	contributes_to	gene	0.60
GAIN	contributes_to	gene	0.60
AND	contributes_to	gene	0.60
Sod1	associated_with	gene	0.50
Sod1	interacts_with	gene	0.50
amyotrophic lateral sclerosis	interacts_with	gene	0.50
GAIN	associated_with	gene	0.50
amyotrophic lateral sclerosis	associated_with	gene	0.50
disease	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SOD1 MUTATIONS

Understanding Entity Pages

Wiki Pages (20)

nimodipine-als

NRF2 Oxidative Stress Pathway

ALS Failed Approaches Analysis

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

oxidative-stress-comparison

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Mitochondrial Dysfunction in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Copper Dyshomeostasis in Neurodegeneration

Splice-Modulating Therapies for Neurodegeneration

TDP-43 Proteinopathy

rankings

Gene-Mechanism-Therapy Causal Chains

Protein Aggregation Comparison in Neurodegeneration

Non-Homologous End Joining in Neurodegeneration