concept

HEXANUCLEOTIDE REPEAT EXPANSIONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEXANUCLEOTIDE REPEAT EXPANSIONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

173Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HEXANUCLEOTIDE REPEAT EXPANSIONS is a concept in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 68 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HEXANUCLEOTIDE REPEAT EXPANSIONS
Key Genes/Proteins	AMYOTROPHIC LATERAL SCLEROSIS
Related Diseases	Dementia, Als, Amyotrophic Lateral Sclerosis, Ms, Neuroinflammation

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HEXANUCLEOTIDE_REPEAT_EXPANSIO["<b>HEXANUCLEOTIDE REPEAT EXPANSIONS</b>"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"causes"| ALS["ALS"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"causes"| FTD["FTD"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| Als["Als"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| Dementia["Dementia"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| Ms["Ms"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"activates"| Neuroinflammation["Neuroinflammation"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"activates"| Inflammation["Inflammation"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| SOD1["SOD1"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| FUS["FUS"]
    ATXN2["ATXN2"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    C9ORF72["C9ORF72"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    SOD1_MUTATIONS["SOD1 MUTATIONS"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    FUS -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    SOD1 -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    ALS -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    FTLD["FTLD"] -.protects against.-> HEXANUCLEOTIDE_REPEAT_EXPANSIO
    DEMENTIA["DEMENTIA"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    GAIN["GAIN"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    ASTROCYTES["ASTROCYTES"] -->|"activates"| HEXANUCLEOTIDE_REPEAT_EXPANSIO

Outgoing (114)

Target	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.70
Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
Aging	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	activates	disease	0.65
Dementia	causes	disease	0.65
Als	treats	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Dementia	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neurodegeneration	causes	disease	0.65
Alzheimer	causes	disease	0.65
Parkinson	causes	disease	0.65
Ftd	causes	disease	0.65
Ms	causes	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Ftd	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Autophagy	associated_with	pathway	0.60
SOD1	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
GRN	protects_against	gene	0.60
NFL	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
ALS	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
LYSOSOME	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
ATG	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60

Incoming (59)

Source	Relation	Type	Str
C9ORF72	associated_with	gene	0.60
ATXN2	therapeutic_target	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ALS	associated_with	gene	0.60
SOD1 MUTATIONS	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
SOD1	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
FTLD	protects_against	gene	0.60
MAPT	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
C9ORF72	protects_against	gene	0.60
LYSOSOME	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
ASTROCYTES	activates	gene	0.60
C9ORF72	causes	gene	0.60
C9ORF72	treats	gene	0.60
AND	therapeutic_target	gene	0.60
ALS	regulates	gene	0.60
GBA	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
GAIN	regulates	gene	0.60
ATP13A2	regulates	gene	0.60
TMEM106B	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
PSEN1	regulates	gene	0.60
LRRK2	regulates	gene	0.60
GRN	regulates	gene	0.60
TAU	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	associated_with	gene	0.60
PARKINSON	causes	gene	0.60
LYSOSOME	causes	gene	0.60
TFEB	causes	gene	0.60
TAU	causes	gene	0.60
GAIN	causes	gene	0.60
AND	associated_with	gene	0.60
ALS	causes	gene	0.60
AUTOPHAGY	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
TDP-43	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HEXANUCLEOTIDE REPEAT EXPANSIONS

Understanding Entity Pages

Summary

Wiki Pages (20)

Corticobasal Degeneration (CBD)

Frontotemporal Dementia (FTD) Mechanistic Pathway

NRF2 Oxidative Stress Pathway

Frontotemporal Dementia (FTD)

ALS Failed Approaches Analysis

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

oxidative-stress-comparison

ftd-tdp-pathology

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

TRA2B Protein - Transformer-2 Beta

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Clinical Trials Dashboard

Splice-Modulating Therapies for Neurodegeneration

TDP-43 Proteinopathy

Gene-Mechanism-Therapy Causal Chains