biological_process

Sleep-Wake

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Sleep-Wake: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

134Connections

0Hypotheses

1Analyses

1Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Biological Process Info

Name	Sleep-Wake
Key Genes/Proteins	CRY, BMAL1, CLOCK, HCRTR2, HCRTR1, GENES
Related Diseases	Diabetes, Obesity, Alzheimer, Als, Neuroinflammation

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Sleep_Wake["Sleep-Wake"] -->|"interacts"| Circadian_Rhythm["Circadian Rhythm"]
    style Circadian_Rhythm fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    CRY["CRY"] -->|"regulates"| Sleep_Wake["Sleep-Wake"]
    style CRY fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"regulates"| Sleep_Wake["Sleep-Wake"]
    style BMAL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CLOCK["CLOCK"] -->|"regulates"| Sleep_Wake["Sleep-Wake"]
    style CLOCK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    HCRTR2["HCRTR2"] -->|"regulates"| Sleep_Wake["Sleep-Wake"]
    style HCRTR2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    HCRTR1["HCRTR1"] -->|"regulates"| Sleep_Wake["Sleep-Wake"]
    style HCRTR1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style Sleep_Wake fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (1)

Target	Relation	Type	Str
Circadian Rhythm	interacts_with	pathway	0.55

Incoming (133)

Source	Relation	Type	Str
CRY	regulates	gene	0.60
BMAL1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
BMAL1	biomarker_for	gene	0.60
CLOCK	biomarker_for	gene	0.60
HCRTR2	regulates	gene	0.60
HCRTR1	regulates	gene	0.60
HCRTR2	associated_with	gene	0.60
HCRTR1	associated_with	gene	0.60
GENES	regulates	gene	0.60
Diabetes	regulates	disease	0.60
Obesity	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Als	regulates	disease	0.60
Neuroinflammation	regulates	disease	0.60
Inflammation	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Ms	regulates	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Ms	activates	disease	0.60
GENES	associated_with	gene	0.60
Cardiovascular	associated_with	disease	0.60
Ms	associated_with	disease	0.60
Neurodegeneration	regulates	disease	0.60
CLOCK	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
PER	expressed_in	gene	0.60
CAMK2A	expressed_in	gene	0.60
CRY	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
PAK1	regulates	gene	0.60
P62	regulates	gene	0.60
ATG7	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
ATG5	regulates	gene	0.60
LC3	regulates	gene	0.60
CLOCK	associated_with	gene	0.60
BMAL1	activates	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
ARNT	activates	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60
SLEEP-WAKE CYCLE	associated_with	gene	0.60
NFL	biomarker_for	gene	0.60
SLEEP-WAKE CYCLE	activates	gene	0.60
CLOCK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Human connectome alterations and network-level dysfunction in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Sleep-Wake

Understanding Entity Pages

Wiki Pages (20)

Clinical Management Guide for CBS/PSP

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

Astrocyte Reactivity Mechanism

Circadian Rhythm in Neurodegeneration

Huntington's Disease

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

protective-strategies-cbs-psp

lithium-tauopathy

Paraventricular Hypothalamic Nucleus (PVN) Neurons

Section 147: Telehealth and Remote Monitoring in CBS/PSP

Tauopathies

Locus Coeruleus Alpha Neurons

Angelman Syndrome

NPAS3 Gene

Histamine

Fatal Familial Insomnia

Experiment Prioritization Index — Neurodegeneration

Idorsia Pharmaceuticals Ltd.