concept

SLEEP-WAKE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLEEP-WAKE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

133Connections

1Hypotheses

0Analyses

1Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SLEEP-WAKE

Pathway Diagram

graph TD
    SLEEP_WAKE["SLEEP-WAKE"]
    SLEEP_WAKE -->|"interacts"| Circadian_Rhythm["Circadian Rhythm"]
    CRY["CRY"] -->|"regulates"| SLEEP_WAKE
    BMAL1["BMAL1"] -->|"regulates"| SLEEP_WAKE
    CLOCK["CLOCK"] -->|"regulates"| SLEEP_WAKE
    HCRTR2["HCRTR2"] -->|"regulates"| SLEEP_WAKE
    HCRTR1["HCRTR1"] -->|"regulates"| SLEEP_WAKE
    GENES["GENES"] -->|"regulates"| SLEEP_WAKE
    Diabetes["Diabetes"] -->|"regulates"| SLEEP_WAKE
    Obesity["Obesity"] -->|"regulates"| SLEEP_WAKE

Outgoing (1)

Target	Relation	Type	Str
Circadian Rhythm	interacts_with	pathway	0.55

Incoming (132)

Source	Relation	Type	Str
Neurodegeneration	associated_with	disease	0.60
Ms	activates	disease	0.60
CLOCK	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
PER	expressed_in	gene	0.60
CAMK2A	expressed_in	gene	0.60
CRY	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
CLOCK	associated_with	gene	0.60
BMAL1	activates	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
ARNT	activates	gene	0.60
PER1	expressed_in	gene	0.60
CRY1	expressed_in	gene	0.60
CRY2	expressed_in	gene	0.60
PER2	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
PER	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
AGING	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
AND	activates	gene	0.60
Diabetes	regulates	disease	0.60
Obesity	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Als	regulates	disease	0.60
Neuroinflammation	regulates	disease	0.60
Inflammation	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Ms	regulates	disease	0.60
AND	regulates	gene	0.60
GENES	regulates	gene	0.60
Alzheimer	biomarker_for	disease	0.60
PAK1	regulates	gene	0.60
P62	regulates	gene	0.60
ATG7	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
ATG5	regulates	gene	0.60
LC3	regulates	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Complement Regulator CD55/CD46 Expression Modulates Microgli	0.380	synaptic-biology	What determines the selectivity of compl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLEEP-WAKE in their description or question text

No additional research found