concept

CLOCK GENE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLOCK GENE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

241Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CLOCK GENE
Related Diseases	Diabetes, Obesity, Cancer, Cardiovascular, Metabolic Syndrome

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CLOCK_GENE["CLOCK GENE"]
    CLOCK_GENE -->|"regulates"| Immune_Cells["Immune Cells"]
    CLOCK_GENE -->|"expressed in"| Diabetes["Diabetes"]
    CLOCK_GENE -->|"expressed in"| Obesity["Obesity"]
    CLOCK_GENE -->|"expressed in"| Cancer["Cancer"]
    CLOCK_GENE -->|"expressed in"| Cardiovascular["Cardiovascular"]
    CLOCK_GENE -->|"expressed in"| Metabolic_Syndrome["Metabolic Syndrome"]
    CLOCK_GENE -->|"regulates"| Aging["Aging"]
    CLOCK_GENE -->|"regulates"| Senescence["Senescence"]
    CLOCK_GENE -->|"regulates"| Als["Als"]
    CLOCK_GENE -->|"regulates"| Inflammation["Inflammation"]
    CIRCADIAN_OUTPUT_GENES["CIRCADIAN OUTPUT GENES"] -->|"expressed in"| CLOCK_GENE
    AND["AND"] -->|"expressed in"| CLOCK_GENE
    BMAL1["BMAL1"] -->|"expressed in"| CLOCK_GENE
    PER["PER"] -->|"expressed in"| CLOCK_GENE
    CLOCK["CLOCK"] -->|"expressed in"| CLOCK_GENE
    CANCER["CANCER"] -->|"expressed in"| CLOCK_GENE
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| CLOCK_GENE

Outgoing (153)

Target	Relation	Type	Str
Immune Cells	regulates	cell_type	0.80
Immune Cell Function	regulates	process	0.80
Diabetes	expressed_in	disease	0.65
Obesity	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Metabolic Syndrome	expressed_in	disease	0.65
Aging	regulates	disease	0.65
Senescence	regulates	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ischemia	regulates	disease	0.65
Cardiac	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Tumor	regulates	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	activates	disease	0.65
Ms	contributes_to	disease	0.65
Parkinson	implicated_in	disease	0.65
Als	contributes_to	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Ataxia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Autoimmune	regulates	disease	0.65

Incoming (88)

Source	Relation	Type	Str
CIRCADIAN OUTPUT GENES	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
PER	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	regulates	gene	0.60
AND	regulates	gene	0.60
BMAL1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
AGING	regulates	gene	0.60
TAZ	regulates	gene	0.60
HIPPO	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
HIF-1Α	regulates	gene	0.60
HIF	regulates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AND	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
CLOCK	activates	gene	0.60
CANCER	interacts_with	gene	0.60
CIRCADIAN CLOCK GENES	regulates	gene	0.60
HIF-1Α	activates	gene	0.60
GENES	regulates	gene	0.60
HIF	activates	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	therapeutic_target	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
PARKINSON	implicated_in	gene	0.60
AND	contributes_to	gene	0.60
AGING	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
NATURAL COMPOUNDS	associated_with	gene	0.60
ARNT	regulates	gene	0.60
EXERCISE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CIRCADIAN RHYTHM	expressed_in	gene	0.60
REST	expressed_in	gene	0.60
ATXN3	expressed_in	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
APP/PS1	activates	gene	0.60
CRY2	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CLOCK GENE

Understanding Entity Pages

Wiki Pages (20)

Clinical Management Guide for CBS/PSP

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

Circadian Rhythm in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

NPAS3 Gene

NF-kB Signaling Pathway in Neurodegeneration

Transcriptional Regulation in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Circadian Rhythm Modulation Therapy

Sleep and Neurodegeneration

Advanced Glycation End Products in Neurodegeneration

Sleep-Wake Cycle

Sleep Disruption in Alzheimer's Disease

Circadian Dysfunction Across Neurodegenerative Diseases

Sleep Architecture Changes in CBS and PSP

Circadian Rhythm Dysfunction in Alzheimer's Disease

sleep-disruption-neurodegeneration