concept

CLOCK GENE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLOCK GENE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

223Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CLOCK GENE
Key Genes/Proteins	AGING, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, Amyloid, Apoptosis

Pathway Diagram

graph TD
    CLOCK_GENE["CLOCK GENE"]
    CLOCK_GENE -->|"regulates"| Immune_Cells["Immune Cells"]
    CLOCK_GENE -->|"expressed in"| Diabetes["Diabetes"]
    CLOCK_GENE -->|"expressed in"| Obesity["Obesity"]
    CLOCK_GENE -->|"expressed in"| Cancer["Cancer"]
    CLOCK_GENE -->|"expressed in"| Cardiovascular["Cardiovascular"]
    CLOCK_GENE -->|"expressed in"| Metabolic_Syndrome["Metabolic Syndrome"]
    CLOCK_GENE -->|"regulates"| Aging["Aging"]
    CLOCK_GENE -->|"regulates"| Senescence["Senescence"]
    CLOCK_GENE -->|"regulates"| Als["Als"]
    CLOCK_GENE -->|"regulates"| Inflammation["Inflammation"]
    CIRCADIAN_OUTPUT_GENES["CIRCADIAN OUTPUT GENES"] -->|"expressed in"| CLOCK_GENE
    AND["AND"] -->|"expressed in"| CLOCK_GENE
    BMAL1["BMAL1"] -->|"expressed in"| CLOCK_GENE
    PER["PER"] -->|"expressed in"| CLOCK_GENE
    CLOCK["CLOCK"] -->|"expressed in"| CLOCK_GENE
    CANCER["CANCER"] -->|"expressed in"| CLOCK_GENE
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| CLOCK_GENE

Outgoing (144)

Target	Relation	Type	Str
Immune Cell Function	regulates	process	0.80
Immune Cells	regulates	cell_type	0.80
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Diabetes	expressed_in	disease	0.65
Obesity	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Metabolic Syndrome	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	activates	disease	0.65
Tumor	regulates	disease	0.65
Als	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ischemia	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cardiac	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
Senescence	regulates	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Ms	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ataxia	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Autoimmune	regulates	disease	0.65
Hepatitis	regulates	disease	0.65
Ms	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
ALS	regulates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65

Incoming (79)

Source	Relation	Type	Str
CIRCADIAN OUTPUT GENES	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
PER	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
CRY	expressed_in	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
SLEEP-WAKE CYCLE	regulates	gene	0.60
CIRCADIAN CLOCK GENES	contributes_to	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
GABA	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
CIRCADIAN RHYTHM	expressed_in	gene	0.60
REST	expressed_in	gene	0.60
ATXN3	expressed_in	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
APP/PS1	activates	gene	0.60
CRY2	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
CIRCADIAN RHYTHM	biomarker_for	gene	0.60
PER	regulates	gene	0.60
SLEEP-WAKE CYCLE	biomarker_for	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
SLEEP-WAKE CYCLE	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
GENES	activates	gene	0.60
GBM	activates	gene	0.60
CRY	activates	gene	0.60
BMAL1	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
AKT	regulates	gene	0.60
ARNT	activates	gene	0.60
ERK	regulates	gene	0.60
JUNB	regulates	gene	0.60
AND	regulates	gene	0.60
GENES	associated_with	gene	0.60
BMAL1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
AGING	regulates	gene	0.60
TAZ	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gamma entrainment corrects AD-related clock gene dysregulati	0.676	alzheimers	Gamma entrainment therapy to restore hip
Clock Gene-Mediated Microglial Reprogramming	0.455	chronobiology	Can circadian interventions reverse micr

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLOCK GENE in their description or question text

No additional research found