concept

SLEEP-WAKE CYCLE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLEEP-WAKE CYCLE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

236Connections

0Hypotheses

1Analyses

50Outgoing

34Incoming

Summary

SLEEP-WAKE CYCLE is a concept in neurodegeneration research. Key relationships include: regulates, biomarker for, causes. Associated with ALS, Als, Alzheimer. Connected to 59 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SLEEP-WAKE CYCLE
Key Genes/Proteins	BMAL1
Related Diseases	Alzheimer, Ms, Dementia, Als, Diabetes

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SLEEP_WAKE_CYCLE["SLEEP-WAKE CYCLE"]
    SLEEP_WAKE_CYCLE -.biomarker for.-> Alzheimer["Alzheimer"]
    SLEEP_WAKE_CYCLE -.biomarker for.-> Ms["Ms"]
    SLEEP_WAKE_CYCLE -.biomarker for.-> Dementia["Dementia"]
    SLEEP_WAKE_CYCLE -.biomarker for.-> Als["Als"]
    SLEEP_WAKE_CYCLE -->|"interacts"| Diabetes["Diabetes"]
    SLEEP_WAKE_CYCLE -->|"interacts"| Obesity["Obesity"]
    SLEEP_WAKE_CYCLE -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    SLEEP_WAKE_CYCLE -->|"regulates"| Inflammation["Inflammation"]
    SLEEP_WAKE_CYCLE -->|"regulates"| ALS["ALS"]
    CIRCADIAN_CLOCK_GENES["CIRCADIAN CLOCK GENES"] -->|"regulates"| SLEEP_WAKE_CYCLE
    Orexin["Orexin"] -->|"regulates"| SLEEP_WAKE_CYCLE
    BMAL1["BMAL1"] -->|"regulates"| SLEEP_WAKE_CYCLE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -.biomarker for.-> SLEEP_WAKE_CYCLE
    AMYLOID_BETA["AMYLOID-BETA"] -.biomarker for.-> SLEEP_WAKE_CYCLE
    TAU["TAU"] -.biomarker for.-> SLEEP_WAKE_CYCLE
    CRY["CRY"] -->|"regulates"| SLEEP_WAKE_CYCLE
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| SLEEP_WAKE_CYCLE
    CLOCK["CLOCK"] -->|"regulates"| SLEEP_WAKE_CYCLE

Outgoing (124)

Target	Relation	Type	Str
Alzheimer	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Dementia	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Diabetes	interacts_with	disease	0.65
Obesity	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
ALS	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	activates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Alzheimer	inhibits	disease	0.65
Depression	associated_with	disease	0.65
Bipolar	regulates	disease	0.65
NFL	biomarker_for	gene	0.60
Sleep-Wake	associated_with	pathway	0.60
CLOCK	activates	gene	0.60
Sleep-Wake	activates	pathway	0.60
Circadian Rhythm	interacts_with	pathway	0.60
CLOCK	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
PER	causes	gene	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
Circadian Rhythm	causes	pathway	0.60
Sleep-Wake Cycle	activates	pathway	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CLOCK	regulates	gene	0.60
GENES	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60

Incoming (112)

Source	Relation	Type	Str
BMAL1	regulates	entity	0.90
OREXIN	regulates	entity	0.90
PER	regulates	entity	0.85
BMAL1	associated_with	gene	0.85
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60
CIRCADIAN RHYTHM	causes	gene	0.60
BMAL1	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
CLOCK	biomarker_for	gene	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
PER	causes	gene	0.60
CLOCK	regulates	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
CLOCK	activates	gene	0.60
GFAP	inhibits	gene	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
TAU PATHOLOGY	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
ALZHEIMER DISEASE	inhibits	gene	0.60
AND	regulates	gene	0.60
HCRTR2	associated_with	gene	0.60
CD8	activates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Human connectome alterations and network-level dysfunction in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLEEP-WAKE CYCLE

Understanding Entity Pages

Summary

Wiki Pages (20)

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

Astrocyte Reactivity Mechanism

Circadian Rhythm in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

protective-strategies-cbs-psp

lithium-tauopathy

Paraventricular Hypothalamic Nucleus (PVN) Neurons

Section 147: Telehealth and Remote Monitoring in CBS/PSP

Tauopathies

Angelman Syndrome

NPAS3 Gene

Fatal Familial Insomnia

Experiment Prioritization Index — Neurodegeneration

Idorsia Pharmaceuticals Ltd.

Kv7.3 Potassium Channel

Sleep and Neurodegeneration

Sleep Dysfunction in Neurodegeneration

Advanced Glycation End Products in Neurodegeneration