Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WNT7B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
WNT7B encodes a secreted glycoprotein that activates canonical β-catenin and non-canonical Wnt pathways, regulating neurodevelopment, synaptic plasticity, and neurodegenerative disease pathology.
| Gene Symbol | WNT7B |
| Full Name | Wnt Family Member 7B |
| Chromosome | 22q13.31 |
| Function | encodes a secreted glycoproteins that functions as a ligand in the Wnt signaling pathway, activating both canonical (β-catenin-dependent) and non-canonical (β-catenin-independent) Wnt pathways. |
| Primary Expression | the developing and adult brain, where it regulates critical processes including neural stem cell proliferation and differentiation, axonal guidance, s |
| Molecular Weight | 39 kDa |
| Amino Acids | 349 aa |
| Pathways | WNT, Wnt, Wnt signaling, Wnt pathway |
| UniProt ID | [Q9H6J4](https://www.uniprot.org/uniprot/Q9H6J4) Protein Length |
| Ensembl ID | ENSG00000188064 |
| GeneCards | WNT7B |
| Human Protein Atlas | WNT7B |
| Associated Diseases | cancer |
| Interactions | YBX1, CANCER, PTEN, PGK1, SMAD2, KRAS |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
WNT7B["<b>WNT7B</b>"]
Pancreatic_Cancer["Pancreatic Cancer"]
WNT7B -->|"activates"| Pancreatic_Cancer
Cancer["Cancer"]
WNT7B -->|"activates"| Cancer
Tumor["Tumor"]
WNT7B -->|"activates"| Tumor
Carcinoma["Carcinoma"]
WNT7B -->|"activates"| Carcinoma
Alzheimer["Alzheimer"]
WNT7B -->|"expressed in"| Alzheimer
Als["Als"]
WNT7B -->|"expressed in"| Als
Neurodegeneration["Neurodegeneration"]
WNT7B -->|"expressed in"| Neurodegeneration
ALS["ALS"]
WNT7B -->|"expressed in"| ALS
CANCER["CANCER"]
WNT7B -->|"activates"| CANCER
YBX1["YBX1"]
WNT7B -->|"activates"| YBX1
Wnt["Wnt"]
WNT7B -->|"activates"| Wnt
Glycolysis["Glycolysis"]
WNT7B -->|"activates"| Glycolysis
GSK3["GSK3"]
WNT7B -->|"expressed in"| GSK3
Wnt["Wnt"]
WNT7B -->|"expressed in"| Wnt
AND["AND"]
WNT7B -->|"expressed in"| AND
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
WNT7B -->|"expressed in"| ALZHEIMER_S_DISEASE
TCF3["TCF3"]
WNT7B -->|"expressed in"| TCF3
PTEN["PTEN"]
PTEN -->|"activates"| WNT7B
PGK1["PGK1"]
PGK1 -->|"activates"| WNT7B
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"expressed in"| WNT7B
WNT["WNT"]
WNT -->|"expressed in"| WNT7B
NEURODEGENERATION["NEURODEGENERATION"]
NEURODEGENERATION -->|"expressed in"| WNT7B
Entorhinal_Cortex["Entorhinal Cortex"]
WNT7B -->|"expressed in"| Entorhinal_Cortex
Cortex["Cortex"]
WNT7B -->|"expressed in"| Cortex
Hippocampus["Hippocampus"]
WNT7B -->|"expressed in"| Hippocampus
Temporal_Lobe["Temporal Lobe"]
WNT7B -->|"expressed in"| Temporal_Lobe
neurodegeneration["neurodegeneration"]
WNT7B -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Pancreatic Cancer | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Neurodegeneration | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| YBX1 | activates | gene | 0.60 |
| TCF3 | expressed_in | gene | 0.60 |
| cancer | associated_with | disease | 0.60 |
| CANCER | activates | gene | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Glycolysis | activates | pathway | 0.60 |
| GSK3 | expressed_in | gene | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
| AND | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
| WNT | expressed_in | gene | 0.60 |
| App | expressed_in | protein | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Entorhinal Cortex | expressed_in | brain_region | 0.55 |
| Temporal Lobe | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
| TEMPORAL LOBE | expressed_in | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PTEN | activates | gene | 0.60 |
| PGK1 | activates | gene | 0.60 |
| SMAD2 | activates | gene | 0.60 |
| SMAD2 | inhibits | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
| WNT | expressed_in | gene | 0.60 |
| NEURODEGENERATION | expressed_in | gene | 0.60 |
| KRAS | activates | gene | 0.60 |
| MAPK | activates | gene | 0.60 |
| WNT | inhibits | gene | 0.60 |
| KRAS | associated_with | gene | 0.60 |
| MAPK | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||