PGK1

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PGK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Als, Breast Cancer, Cancer. Connected to 67 entities in the SciDEX knowledge graph.

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graph TD
    PGK1["<b>PGK1</b>"]
    methylglyoxal["methylglyoxal"]
    PGK1 -->|"produces"| methylglyoxal
    Carcinoma{"Carcinoma"}
    PGK1 -->|"associated with"| Carcinoma
    Cancer{"Cancer"}
    PGK1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    PGK1 -->|"associated with"| Tumor
    PGK1 -->|"therapeutic target"| Tumor
    Als{"Als"}
    PGK1 -->|"therapeutic target"| Als
    PGK1 -->|"therapeutic target"| Carcinoma
    PGK1 -->|"therapeutic target"| Cancer
    PTK2["PTK2"]
    PGK1 -->|"associated with"| PTK2
    Glycolysis(["Glycolysis"])
    PGK1 -->|"associated with"| Glycolysis
    AND["AND"]
    PGK1 -->|"therapeutic target"| AND
    DNA["DNA"]
    PGK1 -->|"therapeutic target"| DNA
    YWHAZ["YWHAZ"]
    YWHAZ -->|"associated with"| PGK1
    VDAC1["VDAC1"]
    VDAC1 -->|"associated with"| PGK1
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"associated with"| PGK1
    CANCER["CANCER"]
    CANCER -->|"associated with"| PGK1
    CANCER -->|"therapeutic target"| PGK1
    TP53["TP53"]
    TP53 -->|"therapeutic target"| PGK1
    GAIN["GAIN"]
    GAIN -->|"therapeutic target"| PGK1
    style PGK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0