The authors demonstrate that two serotonin signaling modulators can ameliorate gut dysmotility in DYRK1A-perturbed models, but the mechanistic basis for this rescue is not explained. This gap limits the rational development of serotonin-based therapeutics for autism-associated GI issues. Gap type: unexplained_observation Source paper: Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility. (None, None, PMID:40050271)
Landscape Summary: How do serotonin signaling modulators rescue gut dysmotility caused by DYRK1A perturbation? is a 0.83 priority gap in neuropharmacology. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How do serotonin signaling modulators rescue gut dysmotility caused by DYRK1A perturbation? — INVOKE-2 (completed)
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