concept

APP/PSEN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APP/PSEN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

50Outgoing

20Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	APP/PSEN1
Key Genes/Proteins	TREM2, AND, APP, TAUOPATHY, OVERVIEW, MICROGLIA
Related Diseases	Cerebral Amyloidosis, Memory Impairment, Alzheimer, Tauopathy, Als

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    APP_PSEN1["APP/PSEN1"]
    APP_PSEN1 -->|"causes"| Cerebral_Amyloidosis["Cerebral Amyloidosis"]
    APP_PSEN1 -->|"causes"| Amyloid_Beta_Accumulation["Amyloid-Beta Accumulation"]
    APP_PSEN1 -->|"causes"| Memory_Impairment["Memory Impairment"]
    APP_PSEN1 -->|"interacts"| Alzheimer["Alzheimer"]
    APP_PSEN1 -->|"interacts"| Tauopathy["Tauopathy"]
    APP_PSEN1 -->|"interacts"| Als["Als"]
    APP_PSEN1 -->|"interacts"| ALS["ALS"]
    APP_PSEN1 -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| APP_PSEN1
    DAP12["DAP12"] -->|"interacts"| APP_PSEN1
    ALZHEIMER["ALZHEIMER"] -->|"interacts"| APP_PSEN1
    APP["APP"] -->|"stabilizes"| APP_PSEN1
    AGING["AGING"] -->|"inhibits"| APP_PSEN1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"inhibits"| APP_PSEN1
    OVERVIEW["OVERVIEW"] -->|"interacts"| APP_PSEN1

Outgoing (52)

Target	Relation	Type	Str
Cerebral Amyloidosis	causes	disease	0.90
Amyloid-Beta Accumulation	causes	process	0.90
Memory Impairment	causes	phenotype	0.85
Alzheimer	interacts_with	disease	0.65
Tauopathy	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Aging	inhibits	disease	0.65
TREM2	interacts_with	gene	0.60
AND	associated_with	gene	0.60
APP	associated_with	gene	0.60
TAUOPATHY	interacts_with	gene	0.60
OVERVIEW	interacts_with	gene	0.60
MICROGLIA	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
TYROBP	associated_with	gene	0.60
DAP12	interacts_with	gene	0.60
PSEN1	associated_with	gene	0.60
CD33	interacts_with	gene	0.60
AND	stabilizes	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
PSEN1	stabilizes	gene	0.60
TYROBP	stabilizes	gene	0.60
Amyloid	stabilizes	pathway	0.60
ST8SIA1	interacts_with	gene	0.60
GD3S	regulates	gene	0.60
AND	regulates	gene	0.60
ASTROCYTES	inhibits	gene	0.60
PSEN1	regulates	gene	0.60
AMYLOID	inhibits	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
Monocyte	interacts_with	cell_type	0.60
Microglia	interacts_with	cell_type	0.60
Dendritic Cell	interacts_with	cell_type	0.60
Macrophage	interacts_with	cell_type	0.60
AGING	inhibits	gene	0.60
Neuron	inhibits	cell_type	0.60
Astrocyte	inhibits	cell_type	0.60
Osteoclast	interacts_with	cell_type	0.60
Amyloid-Beta	inhibits	protein	0.60
Tau	interacts_with	protein	0.60
Amyloid	associated_with	protein	0.60
Rb	inhibits	protein	0.60
App	regulates	protein	0.60
Ras	regulates	protein	0.60
Macrophage	expressed_in	cell_type	0.55
Dendritic Cell	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55

Incoming (20)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
DAP12	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
APP	stabilizes	gene	0.60
AGING	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
APP	regulates	gene	0.60
OVERVIEW	interacts_with	gene	0.60
TAUOPATHY	interacts_with	gene	0.60
AMYLOID	inhibits	gene	0.60
MICROGLIA	interacts_with	gene	0.60
AND	stabilizes	gene	0.60
CD33	interacts_with	gene	0.60
GD3S	regulates	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
PSEN1	regulates	gene	0.60
ST8SIA1	interacts_with	gene	0.60
TYROBP	associated_with	gene	0.60
TREM2	interacts_with	gene	0.60
ASTROCYTES	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

APP/PSEN1

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

Alzheimer's Disease Mechanism Index

Circadian Rhythm in Neurodegeneration

rankings

Clinical Trials Dashboard

Amyloid Cascade Pathway

NACET (N-Acetylcysteine Ethyl Ester)

Gene-Mechanism-Therapy Causal Chains

Protein Aggregation Comparison in Neurodegeneration

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

Cellular Senescence in Neurodegeneration

University of California, Irvine (UCI)

Neuroinflammation Across AD, PD, ALS, FTD, and HD

genetics

AD Biomarker-to-Mechanism Mapping

Amyloid Precursor Protein (APP)

Adaptive Immunity in Neurodegeneration

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

Biomarkers of Alzheimer Disease