concept

EGLN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGLN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

21Outgoing

10Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	EGLN2
Key Genes/Proteins	BMAL1, HIF1A, AMYOTROPHIC LATERAL SCLEROSIS, NEURON, NEUROINFLAMMATION, ASTROCYTES
Related Diseases	Neuroinflammation, Als, Amyotrophic Lateral Sclerosis, Inflammation
Related Pathways	Stem Cell, Interferon Signaling

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    EGLN2["EGLN2"]
    EGLN2 -->|"inhibits"| HIF1A["HIF1A"]
    EGLN2 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    EGLN2 -->|"inhibits"| Als["Als"]
    EGLN2 -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    EGLN2 -->|"activates"| Inflammation["Inflammation"]
    EGLN2 -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    EGLN2 -.protects against.-> NEURON["NEURON"]
    EGLN2 -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    BMAL1["BMAL1"] -->|"inhibits"| EGLN2
    STING["STING"] -->|"activates"| EGLN2
    INFLAMMATION["INFLAMMATION"] -->|"activates"| EGLN2
    ALS["ALS"] -->|"inhibits"| EGLN2
    ASTROCYTES["ASTROCYTES"] -->|"activates"| EGLN2
    GENES["GENES"] -->|"activates"| EGLN2
    ASTROCYTE["ASTROCYTE"] -->|"activates"| EGLN2
    MOTOR_NEURONS["MOTOR NEURONS"] -.protects against.-> EGLN2

Outgoing (21)

Target	Relation	Type	Str
HIF1A	inhibits	gene	0.80
Neuroinflammation	activates	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
NEURON	protects_against	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
Stem Cell	activates	pathway	0.60
Interferon Signaling	activates	pathway	0.60
ASTROCYTES	activates	gene	0.60
Neuron	protects_against	cell_type	0.60
Astrocyte	activates	cell_type	0.60
MAP1B	associated_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
RNA	activates	gene	0.60
STING	activates	gene	0.60
astrocytes	expressed_in	cell_type	0.60
stem cells	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60

Incoming (10)

Source	Relation	Type	Str
BMAL1	inhibits	gene	0.90
STING	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALS	inhibits	gene	0.60
ASTROCYTES	activates	gene	0.60
GENES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
MOTOR NEURONS	protects_against	gene	0.60
RNA	activates	gene	0.60
CDKN1A	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EGLN2

Understanding Entity Pages

Wiki Pages (5)

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

EGLN1 — Egl-9 Family Prolyl Hydroxylase 1

HIF-1α Protein

HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha