gene 2,330 words KG: ATP6V0D1
Contents

ATP6V0D1 — ATPase H+ Transporting V0 Subunit D1

🧬 Gene Info
Gene SymbolATP6V0D1
Full NameATPase H+ Transporting V0 Subunit D1
Chromosome16p13.3
Protein TypeV-ATPase subunit (V0 domain)
Functionencodes a critical subunit of the vacuolar-type H+-ATPase (V-ATPase), a multisubunit proton pump essential for acidification of intracellular compartments throughout the cell.
Primary ExpressionBrain, Liver, Kidney, Ubiquitous
Gene TypeProtein coding
PathwaysAutophagy, Inflammasome
UniProt IDP61421
NCBI Gene ID9114
Ensembl IDENSG00000159720
OMIM618171
GeneCardsATP6V0D1
Human Protein AtlasATP6V0D1
Protein ClassV-ATPase subunit (V0 domain)
Associated DiseasesMelanoma, Tumor
InteractionsACTB, ATG14, ATG16L1, AUTOPHAGY, LYSOSOME, INFLAMMATION
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (2)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (15)

p62 - Sequestosome 1 (SQSTM1)
protein · KG edge: associated_with
Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
NLRP3 Inflammasome Hypothesis in Parkinson's Disease
hypothesis · KG edge: associated_with
PYCARD Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ATP6V0D1 associated_with NLRP3
ATP6V0D1 activates ACTB
ATP6V0D1 associated_with IL6
ATP6V0D1 associated_with LC3
ATP6V0D1 associated_with LAMP1
ATP6V0D1 associated_with PYCARD
ATP6V0D1 associated_with P62
ATP6V0D1 associated_with SNAP29
ATP6V0D1 activates ATG14
ATP6V0D1 associated_with CASP1