gene 1,002 words KG: STAT1
Contents

STAT1 Gene - Signal Transducer and Activator of Transcription 1

🧬 Gene Info
Gene SymbolSTAT1
Full NameSignal Transducer and Activator of Transcription 1
AliasesPage for STAT1 Gene
Chromosome2q32.2
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight84 kDa
Pathwayscascade: ### Activation Mechanism, JAK-STAT signaling, JAK-STAT pathway
UniProt IDP42224
NCBI Gene ID6772
Ensembl IDENSG00000115415
GeneCardsSTAT1
Human Protein AtlasSTAT1
Associated DiseasesAls, Autoimmune, Depression, Infection, Inflammation
Known Drugs/Compoundsberberine, Curcumin, metformin, valproic acid
InteractionsACE, AGING, AKT1, alpha-synuclein, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections858 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

Arginine Methylation Enhancement Therapy
Score: 0.65
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
← Prevpg 2/2

Related Analyses (11)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

ANG — Angiogenin
gene · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

STAT1 regulates INTERFERON_RESPONSE
JAK1 activates STAT1
STAT1 activates HIF1A
STAT1 activates ERRα
STAT1 activates STAT3
STAT1 activates TLR4
STAT1 activates EGFR
CSF2 regulates STAT1
NAMPT regulates STAT1
FGF2 regulates STAT1

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