gene 1,488 words KG: STAT3
Contents

STAT3 Gene

🧬 Gene Info
Gene SymbolSTAT3
Full NameSignal Transducer and Activator of Transcription 3
Chromosome17q21.2
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight92 kDa
Amino Acids770 aa
PathwaysAkt, Amyloid, Angiogenesis, Apoptosis, Autophagy
UniProt ID[P40763](https://www.uniprot.org/uniprot/P40763)
Ensembl IDENSG00000168610
GeneCardsSTAT3
Human Protein AtlasSTAT3
Associated Diseasesacute lung injury, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsAcetyl-CoA, BARICITINIB, Benzo[a]pyrene, curcumin, Curcumin, dimethyl fumarate
InteractionsABCG2, acetyl-CoA, ACETYL-COA, ACHE, ACSL4, Actin
SciDEX HypothesesSpinal Cord Astrocyte Reactivity Convergence
Dual Astrocyte-Microglia Phenotype Synchronization
KG Connections3626 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (68)

Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Sphingolipid Metabolism Reprogramming
Score: 0.62
Netrin-1 Gradient Restoration
Score: 0.59
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
← Prevpg 4/4

Related Analyses (20)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (2)

S-equol-induced ferroptosis mechanism in TNBC cells
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (6)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: regulates
AGO2 (Argonaute-2)
gene · KG edge: inhibits
AIFM1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

IL6 activates STAT3
STAT3 activates VAV1
GPCR regulates STAT3
STAT3 regulates MITOCHONDRION
TSPAN8 interacts_with STAT3
STAT3 regulates MMP9
STAT3 regulates MYC
STAT3 regulates BCL2
TRF33 inhibits STAT3
STAT3 activates GASTRIC_CANCER

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