gene 1,488 words KG: STAT3
Contents

STAT3 Gene

🧬 Gene Info
Gene SymbolSTAT3
Full NameSignal Transducer and Activator of Transcription 3
Chromosome17q21.2
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight92 kDa
Amino Acids770 aa
PathwaysAkt, Amyloid, Angiogenesis, Apoptosis, Autophagy
UniProt ID[P40763](https://www.uniprot.org/uniprot/P40763)
Ensembl IDENSG00000168610
GeneCardsSTAT3
Human Protein AtlasSTAT3
Associated Diseasesacute lung injury, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsAcetyl-CoA, BARICITINIB, Benzo[a]pyrene, curcumin, Curcumin, dimethyl fumarate
InteractionsABCG2, acetyl-CoA, ACETYL-COA, ACHE, ACSL4, Actin
SciDEX HypothesesSpinal Cord Astrocyte Reactivity Convergence
Dual Astrocyte-Microglia Phenotype Synchronization
KG Connections3626 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (68)

DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Phase-Separated Organelle Targeting
Score: 0.73
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Microglial Purinergic Reprogramming
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
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Related Analyses (20)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (2)

S-equol-induced ferroptosis mechanism in TNBC cells
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (6)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: regulates
AGO2 (Argonaute-2)
gene · KG edge: inhibits
AIFM1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

IL6 activates STAT3
STAT3 activates VAV1
GPCR regulates STAT3
STAT3 regulates MITOCHONDRION
TSPAN8 interacts_with STAT3
STAT3 regulates MMP9
STAT3 regulates MYC
STAT3 regulates BCL2
TRF33 inhibits STAT3
STAT3 activates GASTRIC_CANCER

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