gene 845 words KG: SYN1 2026-03-24
kind:genesection:genesstate:published
Contents

SYN1 Gene

🧬 Gene Info
Gene SymbolSYN1
ChromosomeXp11.23
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionPrimarily neuronal
PathwaysMAPK, mapk
Ensembl IDENSG00000102057
GeneCardsSYN1
Human Protein AtlasSYN1
Genomic Span~50 kb
Exon CountMultiple exons (13+)
Alternative SplicingProduces multiple isoforms (I, II, III)
Associated DiseasesALS, Aging, Alzheimer, Alzheimer'S Disease, Ataxia
Known Drugs/CompoundsRAPAMYCIN, rapamycin
InteractionsJUN, ATG7, ACTB, PSD95, KEAP1, NRF2
KG Connections466 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (23)

Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto
Score: 0.45
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (13)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
ATM Gene
gene · KG edge: associated_with
ATG7 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

SYN1 activates SYT1
SYN1 activates TFEB
SYN1 activates TUBB3
SYN1 activates TUBULIN
SYN1 provides_data_for ds-f2c28aed24a7
SYN1 associated_with CTSD
SYN1 associated_with MAP1LC3B
SYN1 associated_with SNAP25
SYN1 associated_with CTSB
SYN1 associated_with SYT1