gene 1,184 words KG: TIMM22
Contents

TIMM22 Gene - Translocase of Inner Mitochondrial Membrane 22

🧬 Gene Info
Gene SymbolTIMM22
Chromosome17p13.2
Protein FamilyTranslocase of inner mitochondrial membrane (TIM) family
Protein TypeMitochondrial Inner Membrane Translocase
Functionis an essential component of the TIM22 complex, which mediates the insertion of carrier proteins into the mitochondrial inner membrane.
Primary ExpressionMitochondrial inner membrane
Subcellular LocalizationMitochondrial inner membrane
Molecular Weight~25 kDa
Amino Acids227 aa
UniProt IDQ9Y5J7
NCBI Gene ID94081
Ensembl IDENSG00000139350
GeneCardsTIMM22
Human Protein AtlasTIMM22
Gene NameTranslocase of Inner Mitochondrial Membrane 22
Associated DiseasesParkinson's Disease, Mitochondrial Disorders
InteractionsHSPE1, OPA1, LAMP2, BNIP3L, SIRT1, HTRA2
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (2)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (15)

ULK1 — UNC-51 Like Kinase 1
gene · KG edge: inhibits
TIMM17B — Translocase of Inner Mitochondrial Membrane 1
gene · KG edge: inhibits
timm17a
gene · KG edge: inhibits
TIMM10 — Mitochondrial Import Inner Membrane Translocas
gene · KG edge: inhibits
TFAM Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

TIMM22 inhibits HSPE1
TIMM22 inhibits OPA1
TIMM22 inhibits LAMP2
TIMM22 inhibits BNIP3L
TIMM22 inhibits SIRT1
TIMM22 inhibits HTRA2
TIMM22 inhibits PARK2
TIMM22 inhibits PINK1
TIMM22 inhibits TIMM17A
TIMM22 inhibits EIF2A