protein 636 words KG: TIMM22 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

TIMM22 Protein

🔬 Protein Info
Gene SymbolTIMM22
Chromosome17p13.2
Protein FamilyTranslocase of inner mitochondrial membrane (TIM) family
Functionis an essential component of the TIM22 complex, which mediates the insertion of carrier proteins into the mitochondrial inner membrane.
Primary ExpressionMitochondrial inner membrane
Subcellular LocalizationMitochondrial inner membrane
Molecular Weight25 kDa
Amino Acids227 aa
UniProt IDQ9Y5J7
GeneCardsTIMM22
Human Protein AtlasTIMM22
GeneTIMM22
Mol. Weight22 kDa
Associated DiseasesParkinson's Disease, Mitochondrial Disorders
InteractionsHSPE1, OPA1, LAMP2, BNIP3L, SIRT1, HTRA2
KG Connections43 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

TIMM17B — Translocase of Inner Mitochondrial Membrane 1
gene · KG edge: inhibits
OMA1 Gene
gene · KG edge: inhibits
NRF1 Gene
gene · KG edge: inhibits
mfn2
gene · KG edge: inhibits
MFF Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

TIMM22 inhibits HSPE1
TIMM22 inhibits OPA1
TIMM22 inhibits LAMP2
TIMM22 inhibits BNIP3L
TIMM22 inhibits SIRT1
TIMM22 inhibits HTRA2
TIMM22 inhibits PARK2
TIMM22 inhibits PINK1
TIMM22 inhibits TIMM17A
TIMM22 inhibits EIF2A