gene 890 words KG: OMA1 2026-03-24
kind:genesection:genesstate:published
Contents

OMA1 Gene

🧬 Gene Info
Gene SymbolOMA1
Full NameOMA1 Metallopeptidase
Chromosome1p36.21
Functionis a mitochondrial inner membrane metallopeptidase that plays a critical role in mitochondrial dynamics, quality control, and stress responses.
Molecular Weight57 kDa
Amino Acids524 aa
PathwaysCgas-Sting, Mitophagy, cGAS-STING Pathway, cGAS-STING pathway, mitophagy
UniProt ID[Q9Y5X4](https://www.uniprot.org/uniprot/Q9Y5X4)
Ensembl IDENSG00000174173
OMIM607356
GeneCardsOMA1
Human Protein AtlasOMA1
Associated Diseasesneurodegeneration
InteractionsTIMM23, MTOR, NRF1, HSPD1, MFN2, MFF
KG Connections114 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: activates
HSPA9 Gene
gene · KG edge: activates
GLI Gene Family
gene · KG edge: activates

Knowledge Graph (12 edges)

OMA1 inhibits TIMM23
OMA1 inhibits MTOR
OMA1 inhibits NRF1
OMA1 inhibits HSPD1
OMA1 inhibits MFN2
OMA1 inhibits MFF
OMA1 inhibits BECN1
OMA1 inhibits LONP1
OMA1 inhibits CEBPB
OMA1 inhibits SPG7