gene 1,951 words KG: TIMM23 2026-03-24
kind:genesection:genesstate:published
Contents

TIMM23 — Translocase of Inner Mitochondrial Membrane 23

🧬 Gene Info
Gene SymbolTIMM23
Full NameTranslocase of Inner Mitochondrial Membrane 23
Chromosome10q11.21
FunctionThe TIM23 complex operates in conjunction with the TOM (Translocase of Outer Mitochondrial Membrane) complex, which recognizes and imports precursor proteins across the outer membrane.
Primary ExpressionHigh in brain, heart, muscle, kidney
Amino Acids222 aa
PathwaysMitophagy
UniProt IDO00231
NCBI Gene ID10098
Ensembl IDENSG00000132268
GeneCardsTIMM23
Human Protein AtlasTIMM23
Partner ProteinFunction
TIMM17A/BRegulatory subunit, controls channel activity
TIMM44Motor attachment, recruits mtHsp70
Associated DiseasesParkinson
InteractionsCALCOCO2, PARKIN, PRKN, NDP52, HSPD1, MTOR
KG Connections85 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Membrane Cholesterol Gradient Modulators
Score: 0.52
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51

Related Analyses (12)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

TIMM17B — Translocase of Inner Mitochondrial Membrane 1
gene · KG edge: inhibits
PTEN Gene
gene · KG edge: interacts_with
OPTN — Optineurin
gene · KG edge: interacts_with
OMA1 Gene
gene · KG edge: inhibits
MFF Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

TIMM23 interacts_with CALCOCO2
TIMM23 interacts_with PARKIN
TIMM23 interacts_with PRKN
TIMM23 interacts_with NDP52
TIMM23 interacts_with HSPD1
TIMM23 inhibits MTOR
TIMM23 inhibits NRF1
TIMM23 inhibits HSPD1
TIMM23 inhibits MFN2
TIMM23 inhibits MFF