| Gene Symbol | TNF |
| Full Name | Tumor Necrosis Factor |
| Aliases | TNF-α |
| Chromosome | 6p21.33 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | immune cells and endothelial cells](/cell-types/endothelial-cells)
- Activates NF-κB and MAPK pathways
- [Predominantly pro-survival sign |
| Molecular Weight | 26 kDa |
| Exons | 3 |
| Pathways | NF-κB signaling, NF-κB, MAPK, PI3K |
| Ensembl ID | ENSG00000232890 |
| GeneCards | TNF |
| Human Protein Atlas | TNF |
| TNFR1 (p55) | Ubiquitous, death domain |
| TNFR2 (p75) | Immune cells, tissue-specific |
| Caspase Activation | Apoptosis pathways |
| Associated Diseases | AD, ALS, AMI, Aging, Alopecia Areata |
| Known Drugs/Compounds | ETANERCEPT, RAPAMYCIN, NAC, METFORMIN, Urolithin A, Andrographis paniculata |
| Interactions | MIR193B5P, OCLN, LMNA, APH1B, APOE, IL6 |
| KG Connections | 5551 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |