Contents

Tau Protein

🔬 Protein Info

Gene Symbol	TAU
Chromosome	17q21.31
Protein Family	MAPT family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons, where they bind to microtubules and promote their polymerization and stability
Subcellular Localization	Axons, Neurons
Molecular Weight	45-65 kDa (isoform dependent)
Amino Acids	441 aa
Pathways	Extracellular Aggregation, Hyperphosphorylation, Neurofibrillary Tangle Formation, Protein Assembly, Synapse Pathology
GeneCards	TAU
Human Protein Atlas	TAU
N-terminal Projection Domain	This region projects away from the microtubule surface and interacts with neuronal plasma membrane components, neural stem cells, and other cytoskeletal elements.
Proline-Rich Domain	Contains multiple PXXP motifs that interact with SH3 domain-containing proteins involved in signaling pathways.
Phosphorylation	The most extensively studied modification, with over 80 potential phosphorylation sites identified. Hyperphosphorylation reduces microtubule binding and promotes aggregation.
Acetylation	Regulates tau aggregation and can be detected in AD brain tissue.
Associated Diseases	AD, Aging, Als, Alzheimer, Alzheimer Disease
Known Drugs/Compounds	12A12, Disease-modifying therapy, DONANEMAB, DONEPEZIL, Flavonoids, Hyperbaric Oxygen Therapy
Interactions	AB, ABCA1, ABCA7, ABI3, ACE, ACE2
SciDEX Hypotheses	TREM2 should remain under review until replicated APOE should remain under review until replicated GFAP should remain under review until replicated (+2 more)
KG Connections	5366 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING