| Gene Symbol | TFEB |
| Aliases | Transcription Factor EB |
| Protein Type | Transcription Factor |
| Target Class | Protein |
| Function | TFEB is constitutively expressed in most cell types, with highest expression in tissues with high lysosomal activity including: |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction |
| Primary Expression | most cell types, with highest expression in tissues with high lysosomal activity including: |
| Subcellular Localization | </th><td>Nucleus (cytoplasm in inactive state)</td></tr> |
| Druggability | Medium (0.50) |
| Clinical Stage | Phase II |
| Molecular Weight | 53 kDa |
| Pathways | mTOR |
| GeneCards | TFEB |
| Human Protein Atlas | TFEB |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia |
| Known Drugs/Compounds | RAPAMYCIN, TREHALOSE, trehalose, hederagenin, QGJZF, bortezomib |
| Interactions | NBR1, MTOR, AMBRA1, ATF6, HSPA5, SQSTM1 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Cell-Type Specific TFEB Modulation The Mitochondrial-Lysosomal Metabolic Coupling Dys TFEB-PGC1α Mitochondrial-Lysosomal Decoupling (+1 more) |
| KG Connections | 2811 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |