protein

NEAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

299Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

A nuclear long non-coding RNA essential for paraspeckle formation and implicated in neurodegenerative diseases including ALS, AD, and PD

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🔬 Protein Info

Gene Symbol	NEAT1
Chromosome	11q13.1
Function	is a nuclear long non-coding RNA that serves as the essential structural scaffold for paraspeckles — nuclear bodies involved in gene expression regulation.
Primary Expression	Ubiquitous, highest in brain, heart, muscle
Subcellular Localization	Nucleus (paraspeckles)
Molecular Weight	~23 kDa (isoform 1), ~20 kDa (isoform 2)
Pathways	Blood-Brain Barrier, Endocytosis, Epigenetic, Microrna, Oxidative Stress
GeneCards	NEAT1
Human Protein Atlas	NEAT1
RNA Type	Long non-coding RNA (lncRNA)
Gene	NEAT1
RNA Length	~23 kb (isoform 1), ~3.7 kb (isoform 2)
Associated Diseases	ALS, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Atherosclerosis, Colorectal Cancer, Huntington's disease
Interactions	PPARG, CDK2, JUN, TDP-43, SRPK1, CD163
KG Connections	299 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    NEAT1["NEAT1"] -->|"associated with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    NEAT1["NEAT1"] -->|"regulates"| TDP_43["TDP-43"]
    NEAT1["NEAT1"] -->|"associated with"| Alzheimer_s_disease["Alzheimer's disease"]
    NEAT1["NEAT1"] -->|"associated with"| Parkinson_s_disease["Parkinson's disease"]
    NEAT1["NEAT1"] -->|"associated with"| Huntington_s_disease["Huntington's disease"]
    NEAT1["NEAT1"] -->|"biomarker for"| Alzheimer_s_disease["Alzheimer's disease"]
    NEAT1["NEAT1"] -->|"biomarker for"| Parkinson_s_disease["Parkinson's disease"]
    NEAT1["NEAT1"] -->|"biomarker for"| Huntington_s_disease["Huntington's disease"]
    NEAT1["NEAT1"] -->|"associated with"| Ms["Ms"]
    NEAT1["NEAT1"] -->|"associated with"| Atherosclerosis["Atherosclerosis"]
    NEAT1["NEAT1"] -->|"regulates"| Als["Als"]
    NEAT1["NEAT1"] -->|"activates"| Ms["Ms"]
    style NEAT1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style TDP_43 fill:#006494,stroke:#333,color:#e0e0e0
    style Alzheimer_s_disease fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson_s_disease fill:#ef5350,stroke:#333,color:#e0e0e0
    style Huntington_s_disease fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (190)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	upregulates	disease	0.95
PARKINSON'S DISEASE	upregulates	disease	0.95
ALS	upregulates	disease	0.95
Motor Neuron Degeneration	associated_with	phenotype	0.90
motor neuron degeneration	regulates	disease	0.90
Neurodegeneration	involved_in	process	0.90
Motor Neuron	expressed_in	cell_type	0.85
Motor Neuron Degeneration	protects_against	phenotype	0.85
Motor Neurons	expressed_in	cell_type	0.85
ALS	associated_with	disease	0.85
colorectal cancer	promotes	disease	0.80
Cell Survival	promotes	process	0.80
Amyotrophic Lateral Sclerosis	exacerbates	disease	0.80
Alzheimer's disease	upregulated_in	disease	0.80
Parkinson's disease	upregulated_in	disease	0.80
Huntington's disease	upregulated_in	disease	0.80
amyotrophic lateral sclerosis	upregulated_in	disease	0.80
Neurodegeneration	contributes_to	process	0.75
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.75
Colorectal Cancer	implicated_in	disease	0.75
TDP-43	regulates	protein	0.70
Amyotrophic Lateral Sclerosis	associated_with	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
Parkinson's disease	associated_with	disease	0.70
Huntington's disease	associated_with	disease	0.70
Alzheimer's disease	biomarker_for	disease	0.70
Parkinson's disease	biomarker_for	disease	0.70
Huntington's disease	biomarker_for	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Aging	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Stroke	activates	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	regulates	disease	0.65
Als	interacts_with	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Huntington	activates	disease	0.65

Incoming (109)

Source	Relation	Type	Str
TDP-43	regulates	protein	0.95
Loss Of TDP-43 Function	downregulates	mechanism	0.95
TARDBP	regulates	protein	0.95
TARDBP	downregulates	protein	0.95
Nuclear TDP-43 Loss	downregulates	mechanism	0.94
Nuclear Tdp-43 Loss	downregulates	mechanism	0.90
TDP-43	binds	protein	0.80
PYCARD	associated_with	gene	0.60
HMOX1	regulates	gene	0.60
CASP1	associated_with	gene	0.60
NAMPT	associated_with	gene	0.60
TNF	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
ATG3	associated_with	gene	0.60
CD44	activates	gene	0.60
CTNNB1	expressed_in	gene	0.60
MYC	therapeutic_target	gene	0.60
SOX2	interacts_with	gene	0.60
ATF2	activates	gene	0.60
CSF1	activates	gene	0.60
BNIP3L	activates	gene	0.60
TNF	activates	gene	0.60
CD163	activates	gene	0.60
STAT3	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
RELA	interacts_with	gene	0.60
TNFRSF21	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
GAPDH	expressed_in	gene	0.60
HUNTINGTIN	associated_with	gene	0.60
TDP-43	inhibits	gene	0.60
SRPK1	activates	gene	0.60
GAS5	expressed_in	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
GAS5	activates	gene	0.60
HIF1A	activates	gene	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
JUN	interacts_with	gene	0.60
MUC1	associated_with	gene	0.60
MUC1	regulates	gene	0.60
MUC1	activates	gene	0.60
MYC	activates	gene	0.60
ZFP36	regulates	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ALS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NEAT1

Understanding Entity Pages

Summary

Wiki Pages (21)

NEAT1 (Nuclear Enriched Abundant Transcript 1)

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Epigenetic Alterations in Alzheimer's Disease

RNA Metabolism Dysregulation in Alzheimer's Disease

Transcriptional Regulation in Neurodegeneration

Neuroinflammation in Parkinson's Disease

TBX2 — T-Box Transcription Factor 2

epigenetics-neurodegeneration

ftd-tdp43-pathway

Epigenetic Changes in PSP

Chromatin Remodeling in Neurodegeneration

Exosome Biogenesis in Neurodegeneration

NF-κB Signaling in Neurodegeneration

TAR DNA-Binding Protein 43 (TDP-43)

Tauopathy

RPL10A — Ribosomal Protein L10A

Non-coding RNAs in Neurodegeneration